Exposure to organophosphorus insecticides and increased risks of health and cancer in US women

• Type of Material: Article
• Authors: Hongbing Sun, Rider University; Michael Leo Sun, Drexel University; Dana Barr, Emory University
• Language: English
• Date: 2020-11-01
• Publisher: ELSEVIER
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: 2020
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.etap.2020.103474
• Title of Journal or Parent Work: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
• Volume: 80
• Start Page: 103474
• End Page: 103474
• Keywords: POPULATION; ASTHMA; health risk; Life Sciences & Biomedicine; Environmental Sciences & Ecology; cancer; MALATHION; METABOLITES; US women; NON-HODGKINS-LYMPHOMA; AGRICULTURAL HEALTH; general population; Science & Technology; Environmental Sciences; Pharmacology & Pharmacy; ARRHYTHMIAS; PESTICIDE APPLICATORS; LIPID-PEROXIDATION; ESTROGEN; Toxicology; organophosphorus insecticides
• Research Categories: Health Sciences, Pharmacy; Health Sciences, Toxicology; Health Sciences, Pharmacology

Abstract

Results of this paper provide evidence that chronic long-term exposure to organophosphorus insecticides poses a significantly higher health risk for US women than for men, based on dialkylphosphate biomarker data from NHANES cycles 2003-2012. The risk of cardiovascular disease for female non-smokers aged 60-85 years in the highest dimethylthiophosphate (DMTP) urinary concentration quartile is 3.0 (odds ratio, OD = 3.0, 95%CI 1.4-6.4) times higher than that in the lowest quartile. Women with higher urinary DMTP concentrations also have significantly higher risk of asthma at the ages 6-39 years and an apparently higher risk of chronic bronchitis at the ages 60-85. Overall cancer risk is significantly higher for female non-smokers aged 60-85 years in the higher urinary DMTP quartiles (OD = 2.7, 95% CI 1.3-5.9). Increasing risks of breast cancer for female smokers and prostate cancer for male smokers aged 60-85 years with higher exposure to organophosphorus insecticides in the US are also significant.