Thiamine for Septic Shock Take Your Vitamins

• Type of Material: Article
• Authors: Tomoko Fuji, Jikei University; Jonathan Sevransky, Emory University
• Language: English
• Date: 2023-09-01
• Publisher: American Thoracic Society
• Publication Version: Final Published Version
• Copyright Statement: © 2023 by the American Thoracic Society
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): https://doi.org/10.1164%2Frccm.202307-1140ED
• Title of Journal or Parent Work: American Journal of Respiratory and Critical Care Medicine
• Volume: 208
• Issue: 5
• Start Page: 513
• End Page: 515
• Grant/Funding Information: none
• Keywords: Thiamine; Sepsis
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Sepsis remains a leading cause of death in hospitals (1). In the presence of timely antibiotics, infection source control, and performance improvement projects, most ancillary therapies for sepsis have not demonstrated benefits in clinical trials (2). Thiamine, also known as vitamin B1, has been investigated for the treatment of sepsis and septic shock, as thiamine deficiency has been reported in patients with sepsis (3). Many clinicians are familiar with the use of thiamine to correct low concentrations in patients with alcohol use disorder, and it has previously been studied in sepsis in conjunction with vitamin C and hydrocortisone (4, 5).