Immunology of Norovirus Infection

• Type of Material: Book Chapter
• Authors: Juan Leon, Emory University; Menira Souza, Emory University; Qiuhong Wang, Emory University; Emily R. Smith, Emory University; Linda J. Saif, Emory University; Christine Moe, Emory University
• Language: English
• Date: 2008-12-31
• Publisher: Emory University Libraries
• Publication Version: Final Published Version
• Copyright Statement: © Springer Science+Business Media B.V. 2008
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1007/978-1-4020-8412-6_9
• Title of Journal or Parent Work: Immunity Against Mucosal Pathogens
• Start Page: 219
• End Page: 262
• Grant/Funding Information: The calicivirus research from Dr. Linda Saif’s lab, and discussed in this chapter, was supported by grant #R01-AI49742 from the NIAID, National Institutes of Health.; Dr. Juan Leon was supported by a postdoctoral fellowship in immunology (Human Immunology Award) from the Irvington Institute for Immunological Research and the Dana Foundation.; We are also grateful to the Emory General Clinical Research Center (GCRC) and their NIH National Center for Research Resources grant number M01 RR00039 for their support of our Emory norovirus human challenge study
• Keywords: Infected Volunteer; Histo Blood Group Antigen; STAT1 Knockout Mouse; Lamina Propia; Norwalk Virus
• Research Categories: Biology, Virology

Abstract

Noroviruses are the leading cause of epidemic non-bacterial gastroenteritis worldwide. Despite their discovery over three decades ago, little is known about the host immune response to norovirus infection. The purpose of this chapter is to review the field of norovirus immunology and discuss the contributions of outbreak investigations, human and animal challenge studies and population-based studies. This chapter will survey both humoral and cellular immunity as well as recent advances in norovirus vaccine development.