Publication

Behavioral Phenotype in the TgF344-AD Rat Model of Alzheimer’s Disease

Downloadable Content

Persistent URL
Last modified
  • 05/14/2025
Type of Material
Authors
    Rachel Michelle Saré, National Institute of Mental Health (NIMH)Spencer K. Cooke, National Institute of Mental Health (NIMH)Leland Krych, National Institute of Mental Health (NIMH)Patricia M. Zerfas, National Institutes of Health (NIH)Robert Cohen, Emory UniversityCarolyn Beebe Smith, National Institute of Mental Health (NIMH)
Language
  • English
Date
  • 2020-06-16
Publisher
  • Frontiers Media S.A.
Publication Version
Copyright Statement
  • © 2020 Saré, Cooke, Krych, Zerfas, Cohen and Smith.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 14
Grant/Funding Information
  • This work was funded by the Intramural Research Program of the National Institute of Mental Health ZIA MH002948 DIRP.
  • RS was also supported by a postdoctoral fellowship from FRAXA.
Supplemental Material (URL)
Abstract
  • Alzheimer’s disease (AD) is a progressive neurodegenerative disease resulting in cognitive decline. A unique rat model, TgF344-AD, recapitulates pathological hallmarks of AD. We used a longitudinal design to address the timing of expression of behavioral phenotypes in male and female TgF344-AD rats. In both sexes, we confirmed an age-dependent buildup of amyloid-β. In the open field, female, but not male, TgF344-AD rats were hypoactive at 6 and 12 months of age but at 18 months the two genotypes were similar in levels of activity response. Both male and female TgF344-AD rats had a deficit in performance on a learning and memory task. Male TgF344-AD, but not female, rats had evidence of hyposmia regardless of age. Rest-activity rhythms followed the typical active/inactive phase in all rats regardless of genotype or age. In males, home cage activity was similar across age and genotype; in females, regardless of genotype animals were less active as they aged. These changes highlight some behavioral markers of disease in the rat model. Early markers of disease may be important in early diagnosis and assessment of efficacy when treatment becomes available.
Author Notes
Keywords
Research Categories
  • Health Sciences, Public Health
  • Health Sciences, Mental Health
  • Psychology, Behavioral

Tools

Relations

In Collection:

Items

Thumbnail Title File Description Date Uploaded Visibility Actions
file details Publication File - vnzj8.pdf Primary Content 2025-05-01 Public Download