Underdiagnosis of posterior communicating artery aneurysm in non-invasive brain vascular studies

• Type of Material: Article
• Authors: Valerie I. Elmalem, Emory University; Patricia Hudgins, Emory University; Beau Benjamin Bruce, Emory University; Nancy J Newman, Emory University; Valerie Biousse, Emory University
• Language: English
• Date: 2011-06
• Publisher: Lippincott, Williams & Wilkins
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2011 by North American Neuro-Ophthalmalogy Society
• Final Published Version (URL): http://journals.lww.com/jneuro-ophthalmology/Fulltext/2011/06000/Underdiagnosis_of_Posterior_Communicating_Artery.2.aspx?WT.mc_id=HPxADx20100319xMP
• Title of Journal or Parent Work: Journal of Neuro-Ophthalmology
• ISSN: 1070-8022
• Volume: 31
• Issue: 2
• Start Page: 103
• End Page: 109
• Grant/Funding Information: This study was supported in part by a departmental grant (Department of Ophthalmology) from Research to Prevent Blindness, Inc. New York, NY, and by NIH grants KL2-RR025009 (Dr. Bruce) and UL1-RR025008 (Drs. Bruce and Biousse).
• Research Categories: Biology, Neuroscience; Health Sciences, Medicine and Surgery; Health Sciences, Opthamology

Abstract

Introduction Expert interpretation of modern noninvasive neuroimaging such as CTA or MRA should detect nearly all aneurysms responsible for an isolated third nerve palsy. Whether a catheter angiogram should still be obtained in cases with negative CTA or MRA remains debated, and mostly relies on whether the noninvasive study was correctly performed and interpreted. The aim of our study was to review the diagnostic strategies used to evaluate patients with isolated aneurysmal third nerve palsy at a large academic center. Methods Retrospective review of all cases with posterior communicating artery (PCom A) aneurysmal third nerve palsies seen at our institution since 2001. Results We identified 417 cases with third nerve palsy, aneurysm, or subarachnoid hemorrhage, among which 17 presented with an acute isolated painful third nerve palsy related to an ipsilateral PCom A aneurysm (mean age 52; range 33–83 years). Patients were classified into 3 groups based on the results of the noninvasive imaging obtained at initial presentation. Group I included 4 cases with subarachnoid hemorrhage on initial non-contrast head CT initially obtained in an emergency department for evaluation of their isolated third nerve palsy. Group II included 5 cases with isolated third nerve palsy and normal non-contrast head CT at presentation, immediately correctly diagnosed with a PCom A aneurysm at the referring institution. Group III included the 8 remaining cases who all had aneurysms that were missed on noninvasive studies at outside institutions. Review of these outside studies at our institution showed a PCom A aneurysm, confirming misinterpretation of these tests by the outside radiologists, rather than inadequate technique. Absence of specific training in neuroradiology and inaccurate clinical information provided to the interpreting radiologist were associated with test misinterpretation at the outside institutions. The average size of PCom A aneurysms causing an isolated third nerve palsy across all 3 groups was 7.3 mm, and was similar in each group. Conclusion Our study suggests that aside from an accurate history, the training and experience of the interpreting radiologist is probably the most important factor in determining the reliability of a noninvasive scan in patients with isolated third nerve palsies.