Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE Study

• Type of Material: Article
• Authors: Robert T. Mankowski, University of Florida; Mylene Aubertin-Leheudre, University of Florida; Daniel P. Beavers, Wake Forest University; Anda Botoseneanu, Yale University; Thomas W. Buford, University of Florida; Timothy Church, Pennington Biomed Res Ctr; Nancy W. Glynn, University of Pittsburgh; Abby C. King, Stanford University; Christine Liu, Boston University; Todd M. Manini, University of Florida; Anthony P. Marsh, Wake Forest University; Mary McDermott, Northwest Med Fac Fdn; Joe Nocera, Emory University; Marco Pahor, University of Florida; Elsa S. Strotmeyer, University of Florida; Stephen D. Anton; The LIFE Research Group
• Language: English
• Date: 2015-10-01
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2015 Elsevier Inc.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.exger.2015.06.018
• Title of Journal or Parent Work: Experimental Gerontology
• ISSN: 0531-5565
• Volume: 70
• Start Page: 32
• End Page: 36
• Grant/Funding Information: Stephen Anton was previously supported by the Thomas H. Maren Foundation.; The LIFE Study is funded by a National Institutes of Health/National Institute on Aging Cooperative Agreement # U01AG22376 and a supplement from the National Heart, Lung and Blood Institute (3U01AG022376).; Support was provided by the University of Florida’s Claude D. Pepper Older Americans Independence Center (NIH/NIA P30AG028740), and Clinical and Translational Science Institute (NIH/NCRR UL1TR000064).; It is sponsored in part by the Intramural Research Program, National Institute on Aging, National Institutes of Health.
• Keywords: Accelerometry; Science & Technology; Aging; Disability; Geriatrics & Gerontology; INDEPENDENCE; Waist circumference; CARDIOMETABOLIC RISK; EXERCISE; Life Sciences & Biomedicine; PHYSICAL-ACTIVITY; GUIDELINES; Glucose; STYLE INTERVENTIONS; BEHAVIOR
• Research Categories: Health Sciences, Rehabilitation and Therapy; Gerontology; Health Sciences, Epidemiology

Abstract

Background: Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. Methods: The association between objectively measured sedentary time (accelerometry) with MetS and MetS components was examined in a large sample of older adults with mobility limitations (N = 1198; mean age = 78.7 ± 5.3 years) enrolled in the Lifestyle Interventions and Independence for Elders (LIFE) study. Participants were divided into tertiles according to percentage of daily sedentary time, and the relation between sedentary time with MetS and MetS components was examined after adjusting for age, sex, ethnicity, and BMI. Results: Participants in the highest sedentary time tertile had significantly higher odds of MetS (OR = 1.54) (95% CI 1.13 to 2.11) in comparison with participants in the lowest tertile (p = 0.03). Participants in the highest sedentary time tertile had larger waist circumference (p = 0.0001) and lower HDL-C (p = 0.0003) than participants in the lowest sedentary time tertile. Conclusions: Sedentary time was strongly related to higher odds of MetS. These results, based on objectively measured sedentary time, suggest that sedentary time may represent an important risk factor for the development of MetS in older adults with high likelihood for disability.