Recurrence patterns after resection of retroperitoneal sarcomas: An eight-institution study from the US Sarcoma Collaborative

• Type of Material: Article
• Authors: Konstantinos Chouliaras, Wake Forest University; Rebecca Senehi, Wake Forest University; Cecilia G. Ethun, Emory University; George Poultsides, Stanford University; Thuy Thuy, Stanford University; Valerie Grignol, Ohio State University; Thomas Clark Gamblin, Medical College of Wisconsin; Kevin K. Roggin, University of Chicago; Jennifer Tseng, University of Chicago; Ryan C. Fields, Washington University in St. Louis; Sharon M. Weber, University of Wisconsin; Gregory B. Russell, Wake Forest University; Edward A. Levine, Wake Forest University; Kenneth Cardona, Emory University; Konstantinos Votanopoulos, Wake Forest University
• Language: English
• Date: 2019-09-01
• Publisher: WILEY
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2019 Wiley Periodicals, Inc.
• Final Published Version (URL): http://dx.doi.org/10.1002/jso.25606
• Title of Journal or Parent Work: JOURNAL OF SURGICAL ONCOLOGY
• Volume: 120
• Issue: 3
• Start Page: 340
• End Page: 347
• Grant/Funding Information: The study was supported by the Wake Forest University Biostatistics shared resource NCI CCSG P30CA012197.
• Keywords: Life Sciences & Biomedicine; Science & Technology; predictors; SURVIVAL; overall survival; RPS; Oncology; Surgery; MANAGEMENT; distant relapse; local relapse; SOFT-TISSUE SARCOMA
• Research Categories: Health Sciences, Oncology; Health Sciences, Medicine and Surgery

Abstract

Background and Objectives: Resection of primary retroperitoneal sarcomas (RPS) has a high incidence of recurrence. This study aims to identify patterns of recurrence and its impact on overall survival. Methods: Adult patients with primary retroperitoneal soft tissue sarcomas who underwent resection in 2000-2016 at eight institutions of the US Sarcoma Collaborative were evaluated. Results: Four hundred and ninety-eight patients were analyzed, with 56.2% (280 of 498) having recurrences. There were 433 recurrences (1-8) in 280 patients with 126 (25.3%) being locoregional, 82 (16.5%) distant, and 72 (14.5%) both locoregional and distant. Multivariate analyses revealed the following: Patient age P =.0002), tumor grade (P =.02), local recurrence (P =.0003) and distant recurrence (P <.0001) were predictors of disease-specific survival. The 1-, 3-, and 5-year survival rate for patients who recurred vs not was 89.6% (standard error [SE] 1.9) vs 93.5% (1.8), 66.0% (3.2) vs 88.4% (2.6), and 51.8% (3.6) vs 83.9% (3.3), respectively, P <.0001. Median survival was 5.3 years for the recurrence vs 11.3+ years for the no recurrence group (P <.0001). Median survival from the time of recurrence was 2.5 years. Conclusions: Recurrence after resection of RPS occurs in more than half of patients independently of resection status or perioperative chemotherapy and is equally distributed between locoregional and distant sites. Recurrence is primarily related to tumor biology and is associated with a significant decrease in overall survival.