Adverse Events of Red Blood Cell Transfusions in Patients with Sickle Cell Disease

• Type of Material: Article
• Authors: Margo Renee Rollins, Emory University; Stella T Chou, University of Pennsylvania
• Language: English
• Date: 2022-08-09
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2022 Elsevier Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): https://doi.org/10.1016%2Fj.transci.2022.103557
• Title of Journal or Parent Work: Transfusion and Apheresis Science
• Volume: 61
• Issue: 5
• Start Page: 103557
• Grant/Funding Information: Corresponding author: Stella T. Chou, ude.pohc@suohc, 3615 Civic Center Boulevard, Abramson Research Building Room 316D, Philadelphia, PA 19104
• Keywords: National Healthcare Safety Network; hematology; sickle cell disease; blood transfusion; Biovigilance Component Hemovigilance Module Surveillance Protocol
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Blood transfusion is a common medical intervention for patients with sickle cell disease (SCD) and disease related complications. While patients with SCD are at risk for all transfusion related adverse events defined by the National Healthcare Safety Network (NHSN) Biovigilance Component Hemovigilance Module Surveillance Protocol, they are uniquely susceptible to certain adverse events. This review discusses risk factors, mitigation strategies, and management recommendations for alloimmunization, hemolytic transfusion reactions, hyperviscosity and transfusion-associated iron overload in the context of SCD.