Exclusion of latecomers yields a patchwork of viral subpopulations within hosts

• Type of Material: Article
• Authors: Anice Lowen, Emory University; Lucas Ferreri, Emory University
• Language: English
• Date: 2023-02-01
• Publisher: PLoS Biology
• Publication Version: Final Published Version
• Copyright Statement: © 2023 Lowen, Ferreri
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1371/journal.pbio.3001994
• Title of Journal or Parent Work: PLoS Biology
• Volume: 21
• Issue: 2
• Start Page: e3001994
• End Page: e3001994
• Grant/Funding Information: The work is supported in part by by the National Institutes of Health (R01 AI127799 to ACL; R01 AI154894 to ACL). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
• Keywords: Humans; Superinfection; Orthomyxoviridae
• Research Categories: Health Sciences, Immunology; Biology, Microbiology

Abstract

Viruses arriving late to an individual cell are blocked from replicating, an effect called superinfection exclusion. A study in PLOS Biology indicates that this exclusion at the level of individual cells gives rise to a heterogenous landscape of infection within a host.