Publication

Arginine Vasopressin Effects on Subjective Judgments and Neural Responses to Same and Other-Sex Faces in Men and Women

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Last modified
  • 03/03/2025
Type of Material
Authors
    James Rilling, Emory UniversityTing Li, Emory UniversityXiangchuan Chen, Emory UniversityPritam Gautam, Emory UniversityEbrahim Haroon, Emory UniversityRichmond R. Thompson, Bowdoin College
Language
  • English
Date
  • 2017-08-21
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2017 Rilling, Li, Chen, Gautam, Haroon and Thompson.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-2392
Volume
  • 8
Issue
  • AUG
Start Page
  • 200
End Page
  • 200
Grant/Funding Information
  • This research was supported by MH087721 from the National Institutes of Mental Health.
  • The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
  • This study was also partially supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR000454.
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Abstract
  • Arginine vasopressin (AVP) influences social and emotional behaviors across a wide range of species. In humans, intranasal AVP has been previously shown to alter physiological responses to and subjective judgments of same-sex faces in both men and women. The present study attempted to elucidate the neural mechanism for these effects by randomizing 40 healthy men and 40 healthy women to treatment with either 40 IU intranasal AVP or a saline placebo approximately 30 min before imaging their brain function with fMRI as they viewed same and other-sex faces. All subjects were also scanned a second time several days later with no treatment to evaluate the persistence of AVP effects over time. AVP acutely increased positive ratings of same-sex faces in women, with some evidence that these effects persisted until the second scan. While AVP had no acute effects on same-sex ratings in men, AVP increased positive ratings of same-sex faces several days later. On the other hand, AVP had no effect on other-sex face judgments in either sex. AVP modulation of brain function was focused on the nucleus accumbens (NAc) and the lateral septum, two reward processing areas involved in the formation of social bonds. AVP provoked acute increases in right NAc and bilateral lateral septum responses to female faces among men, with left lateral septum responses persisting over time while right NAc responses reversed over time. Finally, AVP modulated hypothalamic activation to faces in both men and women. The present study therefore indicates that intranasal AVP affects subjective ratings and neural responses to same and other-sex faces in men and women, with some effects persisting and others emerging over time. Future studies should investigate whether AVP effects are modulated by individual variables such as genotype, personality, or attachment style as previously reported for other nonapeptides.
Author Notes
Keywords
Research Categories
  • Psychology, Behavioral
  • Health Sciences, Public Health

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