Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder

• Type of Material: Article
• Authors: Wenhao Jiang, Georgia State University; Ole A Andreassen, University of Oslo; Ingrid Agartz, University of Oslo; Trine Lagerberg, University of Oslo; Lars T Westlye, University of Oslo; Vince Calhoun, Emory University; Jessica A Turner, Georgia State University
• Language: English
• Date: 2020-01-01
• Publisher: ELSEVIER SCI LTD
• Publication Version: Final Published Version
• Copyright Statement: © 2019 The Authors. Published by Elsevier Inc.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.nicl.2019.101989
• Title of Journal or Parent Work: NEUROIMAGE-CLINICAL
• Volume: 26
• Start Page: 101989
• End Page: 101989
• Grant/Funding Information: The TOP study was supported by the Research Council of Norway (#160181, 190311, 223273, 213837, 249711), the South-East Norway Health Authority (2014114, 2014097, 2017-112), and the Kristian Gerhard Jebsen Stiftelsen (SKGJ- MED- 008) and the European Community's Seventh Framework Programme (FP7/2007–2013), grant agreement no. 602450 (IMAGEMEND).; This study was supported by the National Institutes of Health grant R01-MH094524-01A1 to Turner & Calhoun.
• Keywords: SURFACE-AREA; Science & Technology; PSYCHOSIS; INDEPENDENT COMPONENT ANALYSIS; AMYGDALA; CORTICAL THICKNESS; GRAY-MATTER ABNORMALITIES; SCHIZOPHRENIA; INTERMEDIATE PHENOTYPES; SYMPTOM DIMENSIONS; Neurosciences & Neurology; Neuroimaging; NEGATIVE-SYNDROME-SCALE; Life Sciences & Biomedicine
• Research Categories: Health Sciences, Mental Health; Psychology, Behavioral

Abstract

Bipolar disorder (BD) is a severe manic-depressive illness. Patients with BD have been shown to have gray matter (GM) deficits in prefrontal, frontal, parietal, and temporal regions; however, the relationship between structural effects and clinical profiles has proved elusive when considered on a region by region or voxel by voxel basis. In this study, we applied parallel independent component analysis (pICA) to structural neuroimaging measures and the positive and negative syndrome scale (PANSS) in 110 patients (mean age 34.9 ± 11.65) with bipolar disorder, to examine networks of brain regions that relate to symptom profiles. The pICA revealed two distinct symptom profiles and associated GM concentration alteration circuits. The first PANSS pICA profile mainly involved anxiety, depression and guilty feelings, reflecting mood symptoms. Reduced GM concentration in right temporal regions predicted worse mood symptoms in this profile. The second PANSS pICA profile generally covered blunted affect, emotional withdrawal, passive/apathetic social withdrawal, depression and active social avoidance, exhibiting a withdrawal or apathy dominating component. Lower GM concentration in bilateral parietal and frontal regions showed worse symptom severity in this profile. In summary, a pICA decomposition suggested BD patients showed distinct mood and apathy profiles differing from the original PANSS subscales, relating to distinct brain structural networks.