Consensus recommendations for the use of retinoids in ichthyosis and other disorders of cornification in children and adolescents

• Type of Material: Article
• Authors: Andrea L Zaenglein, Penn State/Hershey Medical Center; Moise L Levy, University of Texas Austin; Nicole S Stefanko, Children’s Hospital of Wisconsin; Latanya T Benjamin, Florida Atlantic University; Anna L Bruckner, University of Colorado, Aurora; Keith Choate, Yale University; Brittany G Craiglow, Yale University; John J DiGiovanna, National Cancer Institute, Bethesda; Lawrence F Eichenfield, University of California San Diego; Peter Elias, University of California San Francisco; Philip Fleckman, University of Washington; Leslie Lawley, Emory University; Richard A Lewis, Baylor College of Medicine; Anne W Lucky, Cincinnati Childrens Hosp; Erin F Mathes, University of California San Francisco; Leonard M Milstone, Yale University; Amy S Paller, Northwestern University; Sonali S Patel, University of Colorado; Dawn H Siegel, Medical College of Wisconsin; Joyce Teng, Stanford University; Sherry A Tanumihardjo, University of Wisconsin, Madison; Lauren Thaxton, University of Texas Austin; Mary L Williams, University of California San Francisco
• Language: English
• Date: 2020-11-10
• Publisher: WILEY
• Publication Version: Final Published Version
• Copyright Statement: © 2020 The Authors. Pediatric Dermatology published by Wiley Periodicals LLC
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1111/pde.14408
• Title of Journal or Parent Work: PEDIATRIC DERMATOLOGY
• Volume: 38
• Issue: 1
• Start Page: 164
• End Page: 180
• Grant/Funding Information: This project was funded by unrestricted educational grants from Sun Pharmaceuticals and the Foundation for Ichthyosis and Related Skin Types (FIRST). Administrative support was provided by the Pediatric Dermatology Research Alliance (PeDRA).
• Keywords: adverse drug effects; topical therapy; PREMATURE EPIPHYSEAL CLOSURE; Dermatology; safety monitoring; ectropion; systemic therapy; HARLEQUIN ICHTHYOSIS; PSYCHIATRIC-DISORDERS; disorder of cornification; quality of life; LAMELLAR ICHTHYOSIS; ichthyosis; iPLEDGE; hyperlipidemia; SYSTEMIC RETINOIDS; ORAL ISOTRETINOIN; Life Sciences & Biomedicine; depression; drug monitoring; RECEIVING ISOTRETINOIN; bone health; OCULAR SURFACE; Pediatrics; Science & Technology; contraception; ERYTHROKERATODERMIA VARIABILIS; retinoid; TOPICAL TAZAROTENE
• Research Categories: Health Sciences, Oncology; Health Sciences, Human Development; Biology, Genetics; Health Sciences, Public Health

Abstract

Topical and systemic retinoids have long been used in the treatment of ichthyoses and other disorders of cornification. Due to the need for long-term use of retinoids for these disorders, often beginning in childhood, numerous clinical concerns must be considered. Systemic retinoids have known side effects involving bone and eye. Additionally, potential psychiatric and cardiovascular effects need to be considered. Contraceptive concerns, as well as the additive cardiovascular and bone effects of systemic retinoid use with hormonal contraception must also be deliberated for patients of childbearing potential. The Pediatric Dermatology Research Alliance (PeDRA) Use of Retinoids in Ichthyosis Work Group was formed to address these issues and to establish best practices regarding the use of retinoids in ichthyoses based on available evidence and expert opinion.