Effects of Subretinal Electrical Stimulation in Mer-KO Mice

• Type of Material: Article
• Authors: Julie A. Mocko, Atlanta Department of Veterans Affairs; Moon Kim, Atlanta Department of Veterans Affairs; Amanda E. Faulkner, Atlanta Department of Veterans Affairs; Yang Cao, Atlanta Department of Veterans Affairs; Vincent T. Ciavatta, Emory University; Machelle Pardue, Emory University
• Language: English
• Date: 2011-06
• Publisher: Association for Research in Vision and Ophthalmology, Inc.
• Publication Version: Final Published Version
• Copyright Statement: © Association for Research in Vision and Ophthalmology
• Final Published Version (URL): http://www.iovs.org/content/52/7/4223
• Title of Journal or Parent Work: Investigative Ophthalmology & Visual Science
• Volume: 52
• Issue: 7
• Start Page: 4223
• End Page: 4230
• Grant/Funding Information: Supported by the Rehabilitation Research and Development Service, Atlanta Department of Veterans Affairs; Research to Prevent Blindness; and a National Institutes of Health core grant (Department of Ophthalmology).
• Research Categories: Health Sciences, Opthamology

Abstract

While merkd mice and RCS rats share the same Mertk mutation and an upregulation of Fgf2 in response to subretinal electrical stimulation (SES), they have different neuroprotective responses to SES. This may be due to faster degeneration of the inner retina in the merkd mice.