Publication

Pediatric high grade glioma: A review and update on tumor clinical characteristics and biology

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Last modified
  • 05/15/2025
Type of Material
Authors
    Jason Fangusaro, Emory University
Language
  • English
Date
  • 2012-12-01
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2012 Fangusaro.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 2234-943X
Volume
  • 2 AUG
Start Page
  • 105
End Page
  • 105
Abstract
  • High grade gliomas (HGG) are one of the most common central nervous system (CNS) tumors encountered in adults, but they only represent approximately 8-12% of all pediatric CNS tumors. Historically, pediatric HGG were thought to be similar to adult HGG since they appear histologically identical; however, molecular, genetic, and biologic data reveal that they are distinct. Similar to adults, pediatric HGG are very aggressive and malignant lesions with few patients achieving long-term survival despite a variety of therapies. Initial treatment strategies typically consist of a gross total resection (GTR) when feasible followed by focal radiotherapy combined with chemotherapy. Over the last few decades, a wealth of data has emerged from basic science and pre-clinical animal models helping to better define the common biologic, genetic, and molecular make-up of these tumors. These data have not only provided a better understanding of tumor biology, but they have also provided new areas of research targeting molecular and genetic pathways with the potential for novel treatment strategies and improved patient outcomes. Here we provide a review of pediatric non-brainstem HGG, including epidemiology, presentation, histology, imaging characteristics, treatments, survival outcomes, and an overview of both basic and translational research. An understanding of all relevant pre-clinical tumor models, including their strengths and pitfalls is essential in realizing improved patient outcomes in this population.
Author Notes
  • *Correspondence: Jason Fangusaro, Pediatric Neuro-Oncology, The Ann & Robert H. Lurie Children’s Hospital of Chicago, Feinberg School of Medicine, Northwestern University, 225 East Chicago Avenue, Box 30, Chicago, IL 60611-2605, USA. e-mail: jfangusaro@luriechildrens.org
Keywords
Research Categories
  • Health Sciences, Oncology
  • Biology, Neuroscience

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