Adjustment disorder and type-specific cancer incidence: a Danish cohort study

• Type of Material: Article
• Authors: Thomas P. Ahern, University of Vermont; Katalin Veres, Aarhus University; Tammy Jiang, Boston University; Dora Kormendine Farkas, Aarhus University; Timothy L Lash, Emory University; Henrik Toft Sorensen, Aarhus University; Jaimie L. Gradus, Aarhus University
• Language: English
• Date: 2018-01-01
• Publisher: Taylor & Francis: STM, Behavioural Science and Public Health Titles
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2018 Acta Oncologica Foundation.
• Final Published Version (URL): http://dx.doi.org/10.1080/0284186X.2018.1465586
• Title of Journal or Parent Work: Acta Oncologica
• ISSN: 0284-186X
• Volume: 57
• Issue: 10
• Start Page: 1367
• End Page: 1372
• Grant/Funding Information: TPA was supported by NIGMS grant number P20GM103644.; This work was supported by the Program for Clinical Research Infrastructure (PROCRIN) established by the Lundbeck Foundation and the Novo Nordisk Foundation; and by NIMH grants 1R01MH110453–01A1 (PI: Gradus) and 1R21MH094551–01A1 (PI: Gradus).
• Keywords: SYSTEM; REGISTRY; Science & Technology; RISK; BREAST-CANCER; PREVALENCE; SELF-REPORTED STRESS; MORTALITY; NATIONWIDE; DIAGNOSES; QUALITY; Oncology; Life Sciences & Biomedicine
• Research Categories: Health Sciences, Epidemiology; Health Sciences, Oncology

Abstract

Background: Although adjustment disorder is common, there is a dearth of research on its physical health consequences. Earlier studies, biological mechanisms and stress-related behaviors suggest that cancer may be a potential sequelae of adjustment disorder. This study examined the association between adjustment disorder and type-specific cancer incidence in a nationwide cohort. Methods: Data were obtained from the comprehensive nationwide medical and administrative registries of Denmark. We calculated the incidence of type-specific cancers from 1995 to 2013 in patients with a prior adjustment disorder diagnosis (n = 58,712), and compared it with the incidence in the general population by calculating standardized incidence ratios (SIRs) with accompanying 95% confidence intervals (CIs). SIRs were adjusted using semi-Bayes shrinkage. Results: The SIR for any type of cancer was 1.0 (95% CI: 0.99, 1.1). Adjustment disorder was associated with a 10% lower rate of immune-related cancers (SIR = 0.9, 95% CI: 0.84, 0.97) and with a 20% higher rate of smoking- and alcohol-related cancers (SIR = 1.2, 95% CI: 1.1, 1.3). We found null associations for hematological (SIR = 1.1, 95% CI: 0.89, 1.3) and hormone-related (SIR = 0.98, 95% CI: 0.91, 1.1) malignancies. After semi-Bayes adjustment, type-specific cancer SIRs indicated no association between adjustment disorder and cancer incidence. Conclusions: This study provides persuasive evidence for a null association between adjustment disorder and type-specific cancer incidence in a nationwide study cohort.