Editorial: Environmental Effect on Neuroinflammation and Neurodegeneration

• Type of Material: Article
• Authors: Monica Renee Langley, Mayo Clinic, Rochester; Srikant Rangaraju, Emory University; Adwitia Dey, Harvard Medical School; Souvarish Sarkar, Harvard Medical School
• Language: English
• Date: 2022-06-21
• Publisher: FRONTIERS MEDIA SA
• Publication Version: Final Published Version
• Copyright Statement: © 2022 Langley, Rangaraju, Dey and Sarkar.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3389/fncel.2022.935190
• Title of Journal or Parent Work: FRONTIERS IN CELLULAR NEUROSCIENCE
• Volume: 16
• Start Page: 935190
• End Page: 935190
• Keywords: Life Sciences & Biomedicine; Neurosciences & Neurology; Science & Technology; neurodegeneration; genetic; neuroinflammation; GWAS; gene-environment interactions; Neurosciences
• Research Categories: Health Sciences, Rehabilitation and Therapy; Health Sciences, Pathology

Abstract

Neurodegenerative disorders like Parkinson's disease and Alzheimer's disease, among others, are characterized by the loss of a specific subset of neurons and glial activation. Genome-wide associated studies (GWAS) have identified various genetical risk factors, and environmental risk factors have been found through epidemiological studies. For example, metals, diet, occupational exposure to pesticides, and pollution, among others, have been shown to play a key role in the manifestation of neurodegeneration and neuroinflammation. Furthermore, interactions between genetic and environmental factors play a key role in these disease etiologies.