Publication

C-Reactive Protein Causes Adult-Onset Obesity Through Chronic Inflammatory Mechanism

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Last modified
  • 05/21/2025
Type of Material
Authors
    Qiling Li, Xi An Jiao Tong UniversityQi Wang, Xi An Jiao Tong UniversityWei Xu, Morehouse School of MedicineYamin Ma, Morehouse School of MedicineQing Wang, Xi An Jiao Tong UniversityDanita Eatman, Morehouse School of MedicineShaojin You, Atlanta VA Medical CenterJin Zou, Clark Atlanta UniversityJames Champion, Morehouse School of MedicineLanbo Zhao, Xi An Jiao Tong UniversityYe Cui, Georgia State UniversityWenzhi Li, Morehouse School of MedicineYangyang Deng, Xi An Jiao Tong UniversityLi Ma, Morehouse School of MedicineBiao Wu, Northwest UniversityGuangdi Wang, Xavier University of LouisianaXiaodong Zhang, Emory UniversityQingwei Wang, Morehouse School of MedicineMohamed A. Bayorh, Morehouse School of MedicineQing Song, Xi An Jiao Tong University
Language
  • English
Date
  • 2020-02-20
Publisher
  • Frontiers Media S.A.
Publication Version
Copyright Statement
  • © 2020 Li, Wang, Xu, Ma, Wang, Eatman, You, Zou, Champion, Zhao, Cui, Li, Deng, Ma, Wu, Wang, Zhang, Wang, Bayorh and Song.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 8
Start Page
  • 18
End Page
  • 18
Grant/Funding Information
  • This work was supported by National Institutes of Health (SC2HL095098, G12MD007602, U54MD007590). This study was supported by the Key Research and Development Project of Shaanxi Provincial Science and Technology Department (2017ZDXM-SF-068), Shaanxi Provincial Collaborative Technology Innovation Plan (2017XT-026, 2018XT-002), and Medical Research Project of Xi'an Social Development Guidance Plan (2017117SF/YX011-3).
Supplemental Material (URL)
Abstract
  • Obesity is characterized by low-grade chronic inflammation. As an acute-phase reactant to inflammation and infection, C-reactive protein (CRP) has been found to be the strongest factor associated with obesity. Here we show that chronic elevation of human CRP at baseline level causes the obesity. The obesity phenotype is confirmed by whole-body magnetic resonance imaging (MRI), in which the total fat mass is 6- to 9- fold higher in the CRP rats than the control rats. Univariate linear regression analysis showed different growth rates between the CRP rats and the control rats, and that the difference appears around 11 weeks old, indicating that they developed adult-onset obesity. We also found that chronic elevation of CRP can prime molecular changes broadly in the innate immune system, energy expenditure systems, thyroid hormones, apolipoproteins, and gut flora. Our data established a causal role of CRP elevation in the development of adult-onset obesity.
Author Notes
Keywords
Research Categories
  • Health Sciences, Immunology
  • Health Sciences, Nutrition
  • Health Sciences, Human Development
  • Biology, Cell

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