Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme

• Type of Material: Article
• Authors: Maureen Wirschell, Emory University; Ryosuke Yamamoto, Emory University; Lea Alford, Emory University; Avanti S Gokhale, Emory University; Anne Gaillard, Sam Houston State University; Winfield S. Sale, Emory University
• Language: English
• Date: 2011-06-15
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2011 Elsevier Inc. All rights reserved.
• Final Published Version (URL): http://dx.doi.org/10.1016/j.abb.2011.04.003
• Title of Journal or Parent Work: Archives of Biochemistry and Biophysics
• ISSN: 0003-9861
• Volume: 510
• Issue: 2
• Start Page: 93
• End Page: 100
• Research Categories: Biology, Cell

Abstract

Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation / dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.