Mortality in US veterans with pulmonary hypertension: a retrospective analysis of survival by subtype and baseline factors

• Type of Material: Article
• Authors: Aaron W. Trammell, Emory University; Amit J. Shah, Emory University; Lawrence S Phillips, Emory University; Michael Hart, Emory University
• Language: English
• Date: 2019-02-19
• Publisher: SAGE Publications (UK and US): Creative Commons Attribution
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s) 2019.
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1177/2045894019825763
• Title of Journal or Parent Work: Pulmonary Circulation
• ISSN: 2045-8932
• Volume: 9
• Issue: 1
• Start Page: 2045894019825763
• End Page: 2045894019825763
• Grant/Funding Information: This work was partially funded from Emory University’s Open Access Publishing Fund.; This work was supported in part by funding from the Department of Veterans Affairs, Biomedical Laboratory Research and Development Office, Merit Review Award (1I01BX001910 to CMH), by NIH NHLBI R01 (HL102167 to CMH), and with resources and the use of facilities at the Atlanta Veterans Affairs Medical Center.; This work was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award number UL1TR002378.
• Keywords: comorbidity; Science & Technology; Cardiac & Cardiovascular Systems; Cardiovascular System & Cardiology; Respiratory System; HOSPITALIZATION; risk factors; HEALTH; THERAPY; pulmonary hypertension; Life Sciences & Biomedicine; ASSOCIATION; OBESITY; UNITED-STATES; DEATH; COHORT; retrospective cohort study; survival; PREDICTING RISK; DISEASE
• Research Categories: Health Sciences, Epidemiology; Health Sciences, Public Health

Abstract

Pulmonary hypertension (PH) occurs when the pulmonary vasculature is itself diseased or becomes affected secondarily by comorbid conditions, commonly left heart or lung disease. The high prevalence of chronic cardiopulmonary conditions among patients served by Veterans Health Administration (VHA) suggests this population may be particularly susceptible to PH. We sought to identify clinical features and outcomes in veterans diagnosed with PH. We utilized the VHA Corporate Data Warehouse to identify veterans diagnosed between January 1, 2003 and September 30, 2015, assess relevant patient characteristics and their survival time. The effects of PH subtype and baseline factors on outcome were estimated by Cox modeling. There were 110,564 veterans diagnosed with PH during the study period. These veterans were predominantly male, had median age 70.2, and had a high burden of comorbid conditions. PH was frequently due to left heart and/or lung disease. Average survival after PH diagnosis was 3.88 years. Compared with other types, PH due to left heart disease, lung disease or both had shorter survival. This large retrospective study of veterans demonstrates the significance of PH due to left heart and/or lung disease which was common and had high risk of death. Multi-comorbidity was common and added to risk. These findings underscore the need for risk assessment tools for subjects with non-Group 1 PH and novel management strategies to improve their outcome. This study details the largest retrospective cohort assembled for evaluation of secondary PH and allows hypothesis-generating inquiries into these common conditions that are rarely prospectively studied.