What's Hot in HIV in 2019-A Basic and Translational Science Summary for Clinicians From IDWeek 2019

• Type of Material: Article
• Authors: Boghuma Titanji, Emory University; Colleen Kelley, Emory University
• Language: English
• Date: 2020-03-01
• Publisher: Oxford University Press Inc.
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1093/ofid/ofaa053
• Title of Journal or Parent Work: Open Forum Infectious Diseases
• Volume: 7
• Issue: 3
• Start Page: ofaa053
• End Page: ofaa053
• Grant/Funding Information: None to report.
• Keywords: Microbiology; Infectious Diseases; Life Sciences & Biomedicine; Immunology; Science & Technology; Therapy; clinicians; HIV; Strategies; updates; translational research
• Research Categories: Health Sciences, Health Care Management; Biology, Microbiology; Health Sciences, Epidemiology; Health Sciences, Immunology

Abstract

The field of HIV research is constantly evolving, and every year brings advances that draw us closer to ending the HIV epidemic. Here, we present a nonexhaustive overview of select notable studies in HIV prevention, cure, and treatment, published in the last year as presented at IDWeek 2019: What’s Hot in HIV Basic Science. The past year brought interesting results on the use of broadly neutralizing antibodies for treatment and prevention, gene-editing approaches to HIV cure, and new ways to measure the HIV reservoir. We also saw encouraging results on novel HIV vaccine delivery strategies and how these may influence effective immune responses. Lastly, in the area of inflammation, some mechanistic insights were made into the contribution of cotrimoxazole prophylaxis and potential new targets to reduce HIV-associated chronic inflammation. The future from where we stand is bright for HIV research, with much more to look forward to in 2020.