Publication

Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection or cystic fibrosis-related diabetes

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Last modified
  • 06/25/2025
Type of Material
Authors
    Ruchi Yadav, The University of GeorgiaQuan-Zhen Li, University of Texas SouthwesternHanwen Huang, The University of GeorgiaS. Louis Bridges, Jr., Weill Cornell Medical CollegeJ. Michelle Kahlenberg, University of Michigan, Ann ArborArlene Stecenko, Emory UniversityBalázs Rada, The University of Georgia
Language
  • English
Date
  • 2023-09-11
Publisher
  • Frontiers
Publication Version
Copyright Statement
  • © 2023 Yadav, Li, Huang, Bridges, Kahlenberg, Stecenko and Rada
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 14
Start Page
  • 1151422
Grant/Funding Information
  • This work was funded by NIH grants: R01HL136707 (Rada), R21AI154343 (Rada), R21AI130504 (Rada), grants of the Cystic Fibrosis Foundation: 701952 (Rada), 438903 (Rada) and by pilot funds provided by the Georgia Clinical and Translational Science Alliance.
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Abstract
  • Introduction While cystic fibrosis (CF) lung disease is characterized by persistent inflammation and infections and chronic inflammatory diseases are often accompanied by autoimmunity, autoimmune reactivity in CF has not been studied in depth. Methods In this work we undertook an unbiased approach to explore the systemic autoantibody repertoire in CF using autoantibody microarrays. Results and discussion Our results show higher levels of several new autoantibodies in the blood of people with CF (PwCF) compared to control subjects. Some of these are IgA autoantibodies targeting neutrophil components or autoantigens linked to neutrophil-mediated tissue damage in CF. We also found that people with CF with higher systemic IgM autoantibody levels have lower prevalence of S. aureus infection. On the other hand, IgM autoantibody levels in S. aureus-infected PwCF correlate with lung disease severity. Diabetic PwCF have significantly higher levels of IgA autoantibodies in their circulation compared to nondiabetic PwCF and several of their IgM autoantibodies associate with worse lung disease. In contrast, in nondiabetic PwCF blood levels of IgA autoantibodies correlate with lung disease. We have also identified other autoantibodies in CF that associate with P. aeruginosa airway infection. In summary, we have identified several new autoantibodies and associations of autoantibody signatures with specific clinical features in CF.
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Keywords
Research Categories
  • Health Sciences, Immunology

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