Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer

• Type of Material: Article
• Authors: Changhyon Yun, Emory University
• Language: English
• Date: 2019-06-26
• Publisher: MDPI
• Publication Version: Final Published Version
• Copyright Statement: © 2019 by the author. Licensee MDPI, Basel, Switzerland.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3390/cancers11070958
• Title of Journal or Parent Work: Cancers
• Volume: 11
• Issue: 7
• Grant/Funding Information: This work was supported by NIH grants R01DK071597, R01DK116799 and the VA Merit award I01BX002540.
• Keywords: GROWTH-FACTOR; NA+/H+ EXCHANGER 3; LYSOPHOSPHOLIPASE-D; LPA RECEPTORS; ULCERATIVE-COLITIS; ABERRANT EXPRESSION; PROTEIN-COUPLED RECEPTOR; inflammation; Science & Technology; MEDIATED PHOSPHORYLATION; Oncology; colorectal cancer; intestine; HUMAN-COLON-CARCINOMA; Life Sciences & Biomedicine; INTESTINAL EPITHELIAL-CELLS; lysophosphatidic acid
• Research Categories: Health Sciences, Oncology; Health Sciences, Medicine and Surgery

Abstract

The intestinal epithelium interacts dynamically with the immune system to maintain its barrier function to protect the host, while performing the physiological roles in absorption of nutrients, electrolytes, water and minerals. The importance of lysophosphatidic acid (LPA) and its receptors in the gut has been progressively appreciated. LPA signaling modulates cell proliferation, invasion, adhesion, angiogenesis, and survival that can promote cancer growth and metastasis. These effects are equally important for the maintenance of the epithelial barrier in the gut, which forms the first line of defense against the milieu of potentially pathogenic stimuli. This review focuses on the LPA-mediated signaling that potentially contributes to inflammation and tumor formation in the gastrointestinal tract.