Poliovirus vaccination options for achieving eradication and securing the endgame

• Type of Material: Article
• Authors: Concepción F Estivariz, Centers for Disease Control and Prevention, Atlanta; Mark A Pallansch, Centers for Disease Control and Prevention, Atlanta; Abhijeet Anand, Centers for Disease Control and Prevention, Atlanta; Steven GF Wassilak, Centers for Disease Control and Prevention, Atlanta; Roland W Sutter, World Health Organization, Geneva; Jay D Wenger, Bill and Melinda Gates Foundation, Seattle; Walter A Orenstein, Emory University
• Language: English
• Date: 2013-06-01
• Publisher: ELSEVIER SCI LTD
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2024 Elsevier B.V.,
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.coviro.2013.05.007
• Title of Journal or Parent Work: CURRENT OPINION IN VIROLOGY
• Volume: 3
• Issue: 3
• Start Page: 309
• End Page: 315
• Keywords: EPIDEMIOLOGY; Science & Technology; SCHEDULES; Life Sciences & Biomedicine; SEROLOGIC RESPONSE; Virology; VACCINES; EXCRETION; POLIOMYELITIS; CLINICAL-TRIAL; EMERGENCE; IMMUNOGENICITY; POTENCY
• Research Categories: Biology, Virology; Health Sciences, Medicine and Surgery

Abstract

In 1988, the World Health Assembly resolved to globally eradicate poliomyelitis. As part of a four-pronged strategy with establishment of enhanced surveillance, institution of national immunization days, strengthening routine immunization, and carrying-out mopping-up activities, oral poliovirus vaccine (OPV) was selected as the vaccine-of-choice for eradication. Massive OPV use decreased the number of polio-endemic countries from >125 countries in 1988 to only 3 in 2012 and led to a >99.9% decrease in polio incidence in the corresponding period. In this communication, we will discuss polio vaccination options to accelerate eradication, to mitigate the risks during the planned withdrawal of type 2 OPV, and to secure eradication for future generations. © 2013 Elsevier B.V. All rights reserved.