Knowledge Domain and Emerging Trends in Ferroptosis Research: A Bibliometric and Knowledge-Map Analysis

• Type of Material: Article
• Authors: Jie Zhang, Beijing University of Chinese Medicine; Luxia Song, Beijing University of Chinese Medicine; Liyan Xu, Emory University; Yixuan Fan, Beijing University of Chinese Medicine; Tong Wang, Beijing University of Chinese Medicine; Wende Tian, China Academy of Chinese Medical Sciences; Jianqing Ju, China Academy of Chinese Medical Sciences; Hao Xu, China Academy of Chinese Medical Sciences
• Language: English
• Date: 2021-06-03
• Publisher: FRONTIERS MEDIA SA
• Publication Version: Final Published Version
• Copyright Statement: © 2021 Zhang, Song, Xu, Fan, Wang, Tian, Ju and Xu
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3389/fonc.2021.686726
• Title of Journal or Parent Work: FRONTIERS IN ONCOLOGY
• Volume: 11
• Start Page: 686726
• End Page: 686726
• Grant/Funding Information: The work was supported by the National Natural Science Foundation of China (No. 81874412), National Natural Science Foundation of China (No.82004145), Beijing Natural Science Foundation (No.7204298), and Central Public Welfare Research Institutes of China Academy of Chinese Medical Sciences (No. ZZ13-YQ-017).
• Keywords: Science & Technology; BIOLOGY; CiteSpace; ferroptosis; Life Sciences & Biomedicine; RECEPTOR; bibliometric; CELL-DEATH; INHIBITION; TOURISM; NANOPARTICLES; FIELD; FORM; GPX4; knowledge-map; MECHANISMS; VOSviewer; Oncology
• Research Categories: Health Sciences, Medicine and Surgery; Computer Science

Abstract

Objectives: To identify the cooperation and impact of authors, countries, institutions, and journals, evaluate the knowledge base, find the hotspot trends, and detect the emerging topics regarding ferroptosis research. Methods: The articles and reviews related to ferroptosis were obtained from the Web of Science Core Collection on November 1, 2020. Two scientometric software (CiteSpace 5.7 and VOSviewer 1.6.15) were used to perform bibliometric and knowledge-map analysis. Results: A total of 1,267 papers were included, in 466 academic journals by 6,867 authors in 438 institutions from 61 countries/regions. The ferroptosis-related publications were increasing rapidly. Cell Death & Disease published the most papers on ferroptosis, while Cell was the top co-cited journal, publication journals and co-cited journals were major in the molecular and biology fields. The United States and China were the most productive countries; meanwhile, the University of Pittsburgh, Columbia University and Guangzhou Medical University were the most active institutions. Brent R Stockwell published the most papers, while Scott J Dixon had the most co-citations; simultaneously, active cooperation existed in ferroptosis researchers. Ten references on reviews, mechanisms, and diseases were regarded as the knowledge base. Five main aspects of ferroptosis research included regulation mechanisms, nervous system injury, cancer, relationships with other types of cell death, and lipid peroxidation. The latest hotspots were nanoparticle, cancer therapy, iron metabolism, and in-depth mechanism. Notably Nrf2 might have turning significance. The emerging topics on ferroptosis research were the further molecular mechanism of ferroptosis and the wider application of ferroptosis-related disease with advanced technology. Conclusion: This study performed a full overview of the ferroptosis research using bibliometric and visual methods. The information would provide helpful references for scholars focusing on ferroptosis.