The Role of Stereotactic Laser Amygdalohippocampotomy in Mesial Temporal Lobe Epilepsy

• Type of Material: Article
• Authors: Robert Gross, Emory University; Jon Willie, Emory University; Daniel Drane, Emory University
• Language: English
• Date: 2016-01-01
• Publisher: WB Saunders
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2016 Elsevier Inc.
• Final Published Version (URL): http://dx.doi.org/10.1016/j.nec.2015.08.004
• Title of Journal or Parent Work: Neurosurgery Clinics of North America
• ISSN: 1042-3680
• Volume: 27
• Issue: 1
• Start Page: 37
• End Page: +
• Grant/Funding Information: Funding was provided to Emory University by way of a clinical study agreement from Visualase, which developed products related to the research described in this article.; D.L. Drane receives funding from the NIH/NINDS (K02 NS070960), which provides support for his work.
• Keywords: Selective amygdalohippocampectomy; QUALITY-OF-LIFE; OUTCOMES; Science & Technology; Life Sciences & Biomedicine; Neuropsychology; MRI; REFRACTORY EPILEPSY; Ablation; Laser; Mesial temporal lobe epilepsy; Neurosciences & Neurology; Surgery; DEFICITS; Memory; TRIAL; Mesial temporal sclerosis; STIMULATION; RECOGNITION; Clinical Neurology; TIME; Anterior temporal lobectomy; SURGERY
• Research Categories: Engineering, Biomedical; Health Sciences, Medicine and Surgery

Abstract

Stereotactic laser amygdalohippocampotomy (SLAH) uses laser interstitial thermal therapy guided by magnetic resonance thermography. This novel intervention can achieve seizure freedom while minimizing collateral damage compared to traditional open surgery, in patients with mesial temporal lobe epilepsy. An algorithm is presented to guide treatment decisions for initial and repeat procedures in patients with and without mesial temporal sclerosis. SLAH may improve access by medication-refractory patients to effective surgical treatments and thereby decrease medical complications, increase productivity, and minimize socioeconomic consequences in patients with chronic epilepsy.