The Children's Oncology Group Radiation Oncology Discipline: 15 Years of Contributions to the Treatment of Childhood Cancer

• Type of Material: Article
• Authors: John C. Breneman, University of Cincinnati; Sarah S. Donaldson, Stanford University; Louis Constine, University of Rochester; Thomas E. Merchant, St. Jude Children’s Research Hospital; Karen Marcus, Harvard Medical School; Arnold C. Paulino, University of Texas MD Anderson Cancer Center; David Followill, University of Texas MD Anderson Cancer Center; Anita Mahajan, Mayo Clinic; Nadia Laack, Mayo Clinic; Natia Esiashvili, Emory University; Daphne Haas-Kogan, Harvard Medical School; Fran Laurie, Imaging and Radiation Oncology Core; Arthur Olch, University of Southern California; Kenneth Ulin, Imaging and Radiation Oncology Core; David Hodgson, Princess Margaret Cancer Centre; Torunn I. Yock, Harvard Medical School; Stephanie Terezakis, Johns Hopkins University; Matt Krasin, St. Jude Children’s Research Hospital; Joseph Panoff, 21st Century Oncology; Paul Chuba, St. John Hospital & Medical Center; Chia-Ho Hua, St. Jude Children’s Research Hospital; Clayton Hess, Emory University; Peter J. Houghton, University of Texas San Antonio; Suzanne Wolden, Memorial Sloan Kettering Cancer Center; Jeff Buchsbaum, National Cancer Institute; Thomas J. Fitzgerald, Imaging and Radiation Oncology Core; John A. Kalapurakal, Northwestern University
• Language: English
• Date: 2018-07-15
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2018 Elsevier Inc.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.ijrobp.2018.03.002
• Title of Journal or Parent Work: International Journal of Radiation Oncology - Biology - Physics
• ISSN: 0360-3016
• Volume: 101
• Issue: 4
• Start Page: 860
• End Page: 874
• Keywords: PHASE-III; TISSUE SARCOMA COMMITTEE; Oncology; CRANIOSPINAL IRRADIATION; GROUP-III RHABDOMYOSARCOMA; WILMS-TUMOR; Radiology, Nuclear Medicine & Medical Imaging; HODGKIN LYMPHOMA; ACUTE LYMPHOBLASTIC-LEUKEMIA; Science & Technology; LOCALIZED EWING SARCOMA; INTERGROUP RHABDOMYOSARCOMA; Life Sciences & Biomedicine; INTERMEDIATE-RISK RHABDOMYOSARCOMA
• Research Categories: Health Sciences, Oncology; Health Sciences, Radiology

Abstract

Purpose: Our aim was to review the advances in radiation therapy for the management of pediatric cancers made by the Children's Oncology Group (COG) radiation oncology discipline since its inception in 2000. Methods and Materials: The various radiation oncology disease site leaders reviewed the contributions and advances in pediatric oncology made through the work of the COG. They have presented outcomes of relevant studies and summarized current treatment policies developed by consensus from experts in the field. Results: The indications and techniques for pediatric radiation therapy have evolved considerably over the years for virtually all pediatric tumor types, resulting in improved cure rates together with the potential for decreased treatment-related morbidity and mortality. Conclusions: The COG radiation oncology discipline has made significant contributions toward the treatment of childhood cancer. Our discipline is committed to continuing research to refine and modernize the use of radiation therapy in current and future protocols with the goal of further improving the cure rates and quality of life of children with cancer.