Clinical and Laboratory Characteristics of Invasive Infections Due to Methicillin-Resistant Staphylococcus aureus Isolates Demonstrating a Vancomycin MIC of 2 Micrograms per Milliliter: Lack of Effect of Heteroresistant Vancomycin-Intermediate S. aureus Phenotype▿

• Type of Material: Article
• Authors: Sarah Satola, Emory University; F. C. Lessa, Centers for Disease Control; Susan M Ray, Emory University; S. N. Bulens, Centers for Disease Control; R. Lynfield, Minnesota Dept. of Health; W. Schaffner, Vanderbilt University; G. Dumyati, University of Rochester; J. Nadle, California Emerging Infections Program; J.B. Patel, Centers for Disease Control
• Language: English
• Date: 2011-04
• Publisher: American Society for Microbiology
• Publication Version: Final Published Version
• Copyright Statement: © 2011, American Society for Microbiology
• Final Published Version (URL): http://jcm.asm.org/content/49/4/1583
• Title of Journal or Parent Work: Journal of Clinical Microbiology
• Volume: 49
• Issue: 4
• Start Page: 1583
• End Page: 1587
• Grant/Funding Information: This study was developed in partnership with the CDC Foundation through a grant from Pfizer Inc. and Astellas Pharma U.S., Inc.
• Research Categories: Biology, Microbiology; Health Sciences, Medicine and Surgery

Abstract

We describe clinical and laboratory characteristics of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections with vancomycin MICs of 2 μg/ml and compare heteroresistant-intermediate S. aureus (hVISA) to non-hVISA. Health care-associated community-onset infections were the most common and resulted in frequent complications and relapses. hVISA-infected patients were more likely to have been hospitalized in the year prior to MRSA culture.