Dynamic Contrast-Enhanced CT Characterization of Xp11.2 Translocation/TFE3 Gene Fusions versus Papillary Renal Cell Carcinomas

• Type of Material: Article
• Authors: Jian He, Nanjing University; Kefeng Zhou, Nanjing University; Bin Zhu, Nanjing University; Gutian Zhang, Nanjing University; Xiaogong Li, Nanjing University; Hongqian Guo, Nanjing University; Weidong Gan, Nanjing University; Zhengyang Zhou, Nanjing University; Tian Liu, Emory University
• Language: English
• Date: 2015
• Publisher: Hindawi Publishing Corporation
• Publication Version: Final Published Version
• Copyright Statement: © 2015 Jian He et al.
• License: Creative Commons Attribution 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1155/2015/298679
• Title of Journal or Parent Work: BioMed Research International
• ISSN: 2314-6133
• Volume: 2015
• Start Page: 1
• End Page: 8
• Grant/Funding Information: This work was supported by the National Natural Science Foundation of China (ID 81572512, 81501441), the Natural Science Foundation of Jiangsu Province (ID BK20131281, BK20150109), Jiangsu Province Health and Family Planning Commission Youth Scientific Research Project (ID Q201508), and Nanjing City Young Health Personnel Training Project (third level; ID: QRX11178).
• Research Categories: Health Sciences, Oncology; Health Sciences, Radiology

Abstract

Purpose. To compare the differences of CT characteristics between renal cell carcinomas (RCCs) associated with Xp11.2 translocation/TFE3 gene fusions (Xp11.2 RCCs) and papillary cell renal cell carcinomas (PRCCs). Methods. CT images and clinical records of 64 patients (25 Xp11.2 RCCs, 15 type 1 and 24 type 2 PRCCs) were analyzed and compared retrospectively. Results. Xp11.2 RCC more frequently affected young (30.7 ± 8.7 years) women (16/25, 64%) with gross hematuria (12/25, 48%), while PRCC more frequently involved middle-aged (54.8 ± 11.1 years) men (28/39, 71.8%) asymptomatically. Xp11.2 RCC tended to be heterogeneous density with some showing circular calcification. Lesion sizes of Xp11.2 RCC (5.4 ± 2.2 cm) and type 2 PRCC (5.7 ± 2.5 cm) were significantly larger than that of type 1 PRCC (3.8 ± 1.8 cm). Xp11.2 RCC contained more cystic components (22/25, 88%) than type 1 PRCC (all solid) and type 2 PRCC (9/24, 36.0%). Type 1 PRCC (13/15, 86.7%) and Xp11.2 RCC (21/25, 84.0%) showed more clear boundary than type 2 PRCC (12/24, 50.0%). Conclusion. CT features including diameter, boundary, attenuation, nature, and circular calcification of the tumor, combined with demographic information and symptoms, may be useful to differentiate Xp11.2 RCC from different subtypes of PRCC.