A Comprehensive Search for Recombinogenic Motifs in the Human Genome

• Type of Material: Article
• Authors: Henry R. Johnston, Johns Hopkins University; David J Cutler, Emory University
• Language: English
• Date: 2013-04-23
• Publisher: Public Library of Science
• Publication Version: Final Published Version
• Copyright Statement: © 2013 Johnston, Cutler.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1371/journal.pone.0062920
• Title of Journal or Parent Work: PLoS ONE
• ISSN: 1932-6203
• Volume: 8
• Issue: 4
• Start Page: e62920
• End Page: e62920
• Grant/Funding Information: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; This work was supported by a grant from the NIH (National Institutes of Health) to D Cutler (5R01HG003461-05).
• Keywords: RECOMBINATION HOTSPOTS; INSTABILITY; Science & Technology - Other Topics; MEIOTIC RECOMBINATION; MAP; Multidisciplinary Sciences; PRDM9; Science & Technology; SPOT
• Research Categories: Biology, Genetics

Abstract

The patterns of male and female recombination vary greatly on a macro scale. A unique motif in each gender, triggering a double strand break at its location, much in the way Chi sites operate in E. coli, could logically explain this difference. As such, we have undertaken a comprehensive search of all small motifs in an attempt to identify one or more that match to the available data. In the end, we conclude that no such motifs appear to exist in the human genome.