Publication

Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder

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Last modified
  • 03/05/2025
Type of Material
Authors
    Paola Matiko Martins Okuda, Universidade Federal de São PauloCheryl Klaiman, Emory UniversityJessica Bradshaw, Children’s Healthcare of AtlantaMorganne Reid, Children’s Healthcare of AtlantaHugo Cogo-Moreira, Universidade Federal de São Paulo
Language
  • English
Date
  • 2017-11-29
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2017 Okuda, Klaiman, Bradshaw, Reid and Cogo-Moreira.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-0640
Volume
  • 8
Issue
  • NOV
Start Page
  • 265
End Page
  • 265
Grant/Funding Information
  • Financial support was provided by the São Paulo Research Foundation—FAPESP (Process no. 2015/04619-0).
Abstract
  • Aim: To determine construct validity and reliability indicators of the Cochrane risk of bias (RoB) tool in the context of randomized clinical trials (RCTs) for autism spectrum disorder (ASD). Methods: Confirmatory factor analysis was used to evaluate a unidimensional model consisting of 9 RoB categorical indicators evaluated across 94 RCTs addressing interventions for ASD. Results: Only five of the nine original RoB items returned good fit indices and so were retained in the analysis. Only one of this five had very high factor loadings. The remaining four indicators had more measurement error than common variance with the RoB latent factor. Together, the five indicators showed poor reliability (ω = 0.687; 95% CI: 0.613-0.761). Conclusion: Although the Cochrane model of RoB for ASD exhibited good fit indices, the majorities of the items have more residual variance than common variance and, therefore, did not adequately capture the RoB in ASD intervention trials.
Author Notes
Keywords
Research Categories
  • Health Sciences, General
  • Psychology, General
  • Health Sciences, Medicine and Surgery

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