Pre-radiotherapy FDG PET predicts radiation pneumonitis in lung cancer

• Type of Material: Article
• Authors: Richard Castillo, Emory University; Ngoc Pham, University of Texas Houston; Sobiya Ansari, University of Texas MD Anderson; Dmitriy Meshkov, University of Texas Houston; Sarah Castillo, University of Texas MD Anderson; Min Li, University of Texas MD Anderson; Adenike Olanrewaju, University of Texas MD Anderson; Brian Hobbs, University of Texas MD Anderson; Edward Castillo, University of Texas MD Anderson; Thomas Guerrero, University of Texas Houston
• Language: English
• Date: 2014-03-13
• Publisher: BMC (part of Springer Nature)
• Publication Version: Final Published Version
• Copyright Statement: © 2014 Castillo et al.; licensee BioMed Central Ltd.
• License: Creative Commons Attribution 2.0 Generic
• Final Published Version (URL): http://dx.doi.org/10.1186/1748-717X-9-74
• Title of Journal or Parent Work: Radiation Oncology
• ISSN: 1748-717X
• Volume: 9
• Issue: 1
• Start Page: 74
• End Page: 74
• Grant/Funding Information: This work was partially funded by the National Institutes of Health through a National Cancer Institute Grant R21CA141833 and through an NIH Director’s New Innovator Award DP2OD007044.; RC was partially supported by an NIH Research Scientist Development Award K01CA181292.
• Keywords: Oncology; NSCLC; RISK; CHEMOTHERAPY; TOMOGRAPHY; ATTENUATION CORRECTION; Life Sciences & Biomedicine; Radiology, Nuclear Medicine & Medical Imaging; RESPIRATORY MOTION; Standard uptake value; CHEMORADIATION; GUIDELINES; INTENSITY-MODULATED RADIOTHERAPY; Radiation pneumonitis; Science & Technology; PET/CT; Imaging biomarker; Thoracic radiotherapy; THERAPY; PULMONARY INFLAMMATION
• Research Categories: Health Sciences, Radiology; Health Sciences, Oncology

Abstract

Background: A retrospective analysis is performed to determine if pre-treatment [18 F]-2-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG PET/CT) image derived parameters can predict radiation pneumonitis (RP) clinical symptoms in lung cancer patients. Methods and Materials: We retrospectively studied 100 non-small cell lung cancer (NSCLC) patients who underwent FDG PET/CT imaging before initiation of radiotherapy (RT). Pneumonitis symptoms were evaluated using the Common Terminology Criteria for Adverse Events version 4.0 (CTCAEv4) from the consensus of 5 clinicians. Using the cumulative distribution of pre-treatment standard uptake values (SUV) within the lungs, the 80th to 95th percentile SUV values (SUV80 to SUV95) were determined. The effect of pre-RT FDG uptake, dose, patient and treatment characteristics on pulmonary toxicity was studied using multiple logistic regression. Results: The study subjects were treated with 3D conformal RT (n = 23), intensity modulated RT (n = 64), and proton therapy (n = 13). Multiple logistic regression analysis demonstrated that elevated pre-RT lung FDG uptake on staging FDG PET was related to development of RP symptoms after RT. A patient of average age and V30 with SUV95 = 1.5 was an estimated 6.9 times more likely to develop grade ≥ 2 radiation pneumonitis when compared to a patient with SUV95 = 0.5 of the same age and identical V30. Receiver operating characteristic curve analysis showed the area under the curve was 0.78 (95% CI = 0.69 - 0.87). The CT imaging and dosimetry parameters were found to be poor predictors of RP symptoms. Conclusions: The pretreatment pulmonary FDG uptake, as quantified by the SUV95, predicted symptoms of RP in this study. Elevation in this pre-treatment biomarker identifies a patient group at high risk for post-treatment symptomatic RP.