Design, rationale, and initiation of the Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial: A report from the Cardiothoracic Surgical Trials Network

• Type of Material: Article
• Authors: Peter K. Smith, Duke University; Robert E. Michler, Montefiore-Einstein Heart Center; Y. Joseph Woo, University of Pennsylvania; John H. Alexander, Duke University; John D. Puskas, Emory University; David A. D'Alessandro, Montefiore-Einstein Heart Center; Rebecca T. Hahn, Columbia University; Judson B. Williams, Duke University; John M. Dent, University of Virginia; T. Bruce Ferguson, Jr., East Carolina University; Ellen Moquete, Mt Sinai School of Medicine; Pierre Page, Hôpital du Sacré-Cœur de Montréal; Neal O. Jeffries, National Heart, Lung, and Blood Institute; Patrick T. O'Gara, Brigham & Women's Hospital; Deborah D. Ascheim, Mt Sinai School of Medicine
• Language: English
• Date: 2012-01-01
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2012 by The American Association for Thoracic Surgery.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.jtcvs.2011.05.006
• Title of Journal or Parent Work: Journal of Thoracic and Cardiovascular Surgery
• ISSN: 0022-5223
• Volume: 143
• Issue: 1
• Start Page: 111
• End Page: U175
• Grant/Funding Information: National Heart Lung and Blood Institute; Canadian Institute of Health Research; National Institute of Neurological Diseases and Stroke
• Keywords: Life Sciences & Biomedicine; Surgery; Cardiac & Cardiovascular Systems; ECHOCARDIOGRAPHY; LONG-TERM SURVIVAL; REVASCULARIZATION; Respiratory System; MYOCARDIAL-INFARCTION; Cardiovascular System & Cardiology; HEART-FAILURE; DISEASE; Science & Technology; IMPACT
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Objective: Patients with coronary artery disease complicated by moderate ischemic mitral regurgitation have demonstrably poorer outcome than do patients with coronary artery disease but without mitral regurgitation. The optimal treatment of this condition has become increasingly controversial, and a randomized trial evaluating current practices is warranted. Methods: We describe the design and initial execution of the Cardiothoracic Surgical Trials Network Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial. Results: This is an ongoing prospective, multicenter, randomized, controlled clinical trial designed to test the safety and efficacy of mitral repair in addition to coronary artery bypass grafting in the treatment of moderate ischemic mitral regurgitation. Conclusions: The results of the Cardiothoracic Surgical Trials Network Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial will provide long-awaited information on controversial therapies for this morbid disease process.