Publication

Editorial: Complement in the Development and Regeneration of the Nervous System

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  • 05/20/2025
Type of Material
Authors
    Faith H Brennan, The Ohio State UniversityLiam G Coulthard, Royal Brisbane and Women’s HospitalAli M Alawieh, Emory UniversityOrly Reiner, Weizmann Institute of Science, RehovotMarcela Pekna, University of Gothenburg
Language
  • English
Date
  • 2021-05-10
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2021 Brennan, Coulthard, Alawieh, Reiner and Pekna
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Title of Journal or Parent Work
Volume
  • 12
Grant/Funding Information
  • FB is supported by the Wings for Life Spinal Research Foundation.
Abstract
  • The complement system is an evolutionarily ancient arm of the innate immune system. It is composed of over 40 proteins, receptors and regulators that interact in a cascade manner to protect the host against pathogens (1). The soluble circulating complement proteins are mainly produced by hepatocytes. However, it is now well established that complement factors are expressed throughout the body, including in the central nervous system (CNS). In recent years, complement factors have been shown to control major aspects of CNS development, health, injury and disease (2–4). This Research Topic gathers the latest contributions to how complement factors interact with the nervous system, providing new mechanistic insight into neurodevelopment, cognitive function, myelination, and CNS infection. Review articles highlight roles for complement in development and degeneration of the visual system, and also the status of translation and clinical trials for complement-targeted therapeutics.
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Research Categories
  • Health Sciences, Medicine and Surgery

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