Structure, Process, and Annual ICU Mortality Across 69 Centers: United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study

• Type of Material: Article
• Authors: William Checkley, Johns Hopkins University; Greg Martin, Emory University; Samuel M Brown, Intermountain Medical Center; Steven Y Chang, University of Medicine and Dentistry of New Jersey; Ousama Dabbagh, University of Missouri Columbia; Richard D Fremont, Meharry Medical College; Timothy D Girard, Vanderbilt University; Todd W Rice, Vanderbilt University; Micheal D Howell, Beth Israel Deaconess Medical Center; Steven B Johnson, University of Maryland; James O'Brien, Ohio State University; Pauline K Park, University of Michigan Health System; Stephen M Pastores, Memorial Sloan Kettering Cancer Center; Namrata T Patil, Brigham & Women's Hospital; Anthony P Pietropaoli, University of Rochester; Maryann Putman, Inova Fairfax Hospital; Leo Rotello, Suburban Hospital; Jaonathan Siner, Yale University; Sahul Sajid, Beth Israel Deaconess Medical Center; David J Murphy, Emory University; Jonathan Sevransky, Emory University
• Language: English
• Date: 2014-02-01
• Publisher: Lippincott, Williams & Wilkins
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2013 by the Society of Critical Care Medicine and Lippincott.
• Final Published Version (URL): http://dx.doi.org/10.1097/CCM.0b013e3182a275d7
• Title of Journal or Parent Work: Critical Care Medicine
• ISSN: 0090-3493
• Volume: 42
• Issue: 2
• Start Page: 344
• End Page: 356
• Grant/Funding Information: William Checkley was supported by a Pathway to Independence Award (R00 HL096955) from the National Heart, Lung and Blood Institute, National Institutes of Health.; Greg S. Martin was supported in part by R01 FD003440,P50 AA013757 and UL1 TR000454.; Jonathan E Sevransky was supported in part by K23 GM071399.
• Keywords: INTENSIVE-CARE-UNIT; MODEL; Science & Technology; VOLUME; PATIENT OUTCOMES; intensivist; protocols; MANAGEMENT; MEDICINE; intensive care unit administration; General & Internal Medicine; HOSPITAL MORTALITY; Life Sciences & Biomedicine; Critical Care Medicine; ILL PATIENTS; intensive care unit management; ACUTE LUNG INJURY; structure; MECHANICAL VENTILATION; process
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

OBJECTIVE:: Hospital-level variations in structure and process may affect clinical outcomes in ICUs. We sought to characterize the organizational structure, processes of care, use of protocols, and standardized outcomes in a large sample of U.S. ICUs. DESIGN:: We surveyed 69 ICUs about organization, size, volume, staffing, processes of care, use of protocols, and annual ICU mortality. SETTING:: ICUs participating in the United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study. SUBJECTS:: Sixty-nine intensivists completed the survey. MEASUREMENTS AND MAIN RESULTS:: We characterized structure and process variables across ICUs, investigated relationships between these variables and annual ICU mortality, and adjusted for illness severity using Acute Physiology and Chronic Health Evaluation II. Ninety-four ICU directors were invited to participate in the study and 69 ICUs (73%) were enrolled, of which 25 (36%) were medical, 24 (35%) were surgical, and 20 (29%) were of mixed type, and 64 (93%) were located in teaching hospitals with a median number of five trainees per ICU. Average annual ICU mortality was 10.8%, average Acute Physiology and Chronic Health Evaluation II score was 19.3, 58% were closed units, and 41% had a 24-hour in-house intensivist. In multivariable linear regression adjusted for Acute Physiology and Chronic Health Evaluation II and multiple ICU structure and process factors, annual ICU mortality was lower in surgical ICUs than in medical ICUs (5.6% lower [95% CI, 2.4-8.8%]) or mixed ICUs (4.5% lower [95% CI, 0.4-8.7%]). We also found a lower annual ICU mortality among ICUs that had a daily plan of care review (5.8% lower [95% CI, 1.6-10.0%]) and a lower bed-to-nurse ratio (1.8% lower when the ratio decreased from 2:1 to 1.5:1 [95% CI, 0.25-3.4%]). In contrast, 24-hour intensivist coverage (p = 0.89) and closed ICU status (p = 0.16) were not associated with a lower annual ICU mortality. CONCLUSIONS:: In a sample of 69 ICUs, a daily plan of care review and a lower bed-to-nurse ratio were both associated with a lower annual ICU mortality. In contrast to 24-hour intensivist staffing, improvement in team communication is a low-cost, process-targeted intervention strategy that may improve clinical outcomes in ICU patients.