Association of Objectively Measured Physical Activity With Cardiovascular Risk in Mobility-limited Older Adults

• Type of Material: Article
• Authors: Jodi D. Fitzgerald, University of Florida; Lindsey Johnson, University of Florida; Don G. Hire, Wake Forest School of Medicine; Walter T. Ambrosius, Wake Forest School of Medicine; Stephen D. Anton, University of Florida; John A. Dodson, New York University; Anthony P. Marsh, Wake Forest University; Mary M. McDermott, Northwestern University; Joe Nocera, Emory University; Catrine Tudor-Locke, Pennington Biomedical Research Center; Daniel K. White, Boston University; Veronica Yank, Stanford University; Marco Pahor, University of Florida; Todd M. Manini, University of Florida; Thomas W. Buford, University of Florida
• Language: English
• Date: 2015-02-01
• Publisher: Wiley Open Access: Creative Commons Attribution Non-Commercial
• Publication Version: Final Published Version
• Copyright Statement: © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1161/JAHA.114.001288
• Title of Journal or Parent Work: Journal of the American Heart Association
• ISSN: 2047-9980
• Volume: 4
• Issue: 2
• Start Page: e001288
• End Page: e001288
• Grant/Funding Information: The Lifestyle Interventions and Independence for Elders Study is funded by a National Institutes of Health (NIH)/National Institute on Aging Cooperative Agreement UO1 AG22376 and a supplement from the National Heart, Lung, and Blood Institute 3U01AG022376‐05A2S, and sponsored in part by the Intramural Research Program, National Institute on Aging, NIH.; Dr Roger Fielding (Tufts University) is partially supported by the US Department of Agriculture, under agreement No. 58‐1950‐0‐014.; Tufts University is also supported by the Boston Rehabilitation Outcomes Center (1R24HD065688‐01A1).; LIFE investigators are also partially supported by the following: Dr Thomas Gill (Yale University) is the recipient of an Academic Leadership Award (K07AG3587) from the National Institute on Aging.; Dr Carlos Fragoso (Spirometry Reading Center, Yale University) is the recipient of a Career Development Award from the Department of Veterans Affairs.; The research is also partially supported by the Claude D. Pepper Older Americans Independence Centers at the University of Florida (1 P30 AG028740), Tufts University (1P30AG031679), University of Pittsburgh (P30 AG024827), Wake Forest University (P30AG021332), Yale University (P30AG021342), and the NIH/NCRR CTSA at Stanford University (UL1 RR025744).
• Keywords: Life Sciences & Biomedicine; US ADULTS; accelerometry; UNITED-STATES; HEALTH; LIFE-STYLE INTERVENTIONS; SEDENTARY TIME; AMERICAN-HEART-ASSOCIATION; SITTING TIME; METABOLIC RISK; TELEVISION VIEWING TIME; Cardiac & Cardiovascular Systems; Framingham; aging; DISEASE; Cardiovascular System & Cardiology; CVD; physical activity; Science & Technology
• Research Categories: Health Sciences, Public Health; Health Sciences, Epidemiology

Abstract

BACKGROUND: Data are sparse regarding the impacts of habitual physical activity (PA) and sedentary behavior on cardiovascular (CV) risk in older adults with mobility limitations.METHODS AND RESULTS: This study examined the baseline, cross-sectional association between CV risk and objectively measured PA among participants in the Lifestyle Interventions and Independence for Elders (LIFE) study. The relationship between accelerometry measures and predicted 10-year Hard Coronary Heart Disease (HCHD) risk was modeled by using linear regression, stratified according to CVD history. Participants (n=1170, 79±5 years) spent 642±111 min/day in sedentary behavior (ie, <100 accelerometry counts/min). They also spent 138±43 min/day engaging in PA registering 100 to 499 accelerometry counts/min and 54±37 min/day engaging in PA ≥500 counts/min. Each minute per day spent being sedentary was associated with increased HCHD risk among both those with (0.04%, 95% CI 0.02% to 0.05%) and those without (0.03%, 95% CI 0.02% to 0.03%) CVD. The time spent engaging in activities 100 to 499 as well as ≥500 counts/min was associated with decreased risk among both those with and without CVD (P<0.05). The mean number of counts per minute of daily PA was not significantly associated with HCHD risk in any model (P>0.05). However, a significant interaction was observed between sex and count frequency (P=0.036) for those without CVD, as counts per minute was related to HCHD risk in women (β=-0.94, -1.48 to -0.41; P<0.001) but not in men (β=-0.14, -0.59 to 0.88; P=0.704).CONCLUSIONS: Daily time spent being sedentary is positively associated with predicted 10-year HCHD risk among mobility-limited older adults. Duration, but not intensity (ie, mean counts/min), of daily PA is inversely associated with HCHD risk score in this population-although the association for intensity may be sex specific among persons without CVD.CLINICAL TRIAL REGISTRATION URL: www.clinicaltrials.gov Unique identifier: NCT01072500.