Viral and host control of cytomegalovirus maturation

• Type of Material: Article
• Authors: Ritesh Tandon, Emory University; Edward S Mocarski, Emory University
• Language: English
• Date: 2012-08
• Publisher: Elsevier (Cell Press)
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2012 Elsevier Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.tim.2012.04.008
• Title of Journal or Parent Work: Trends in Microbiology
• ISSN: 0966-842X
• Volume: 20
• Issue: 8
• Start Page: 392
• End Page: 401
• Grant/Funding Information: Research in the Mocarski lab is supported by PHS grants (RO1 AI020211 and AI030363).
• Keywords: nuclear egress; nucleocapsids; Betaherpesviruses; replication; envelope
• Research Categories: Biology, Microbiology

Abstract

Maturation in herpesviruses initiates in the nucleus of the infected cell with encapsidation of viral DNA to form nucleocapsids and concludes with envelopment in the cytoplasm to form infectious virions that egress the cell. The entire process of virus maturation is orchestrated by protein-protein interactions and enzymatic activities of viral and host origin. Viral tegument proteins play important roles in maintaining the structural stability of capsids and directing the acquisition of virus envelope. Envelopment occurs at modified host membranes and exploits host vesicular trafficking. In this review, we summarize the current knowledge and concepts in human cytomegalovirus (HCMV) maturation and their parallels in other herpesviruses with an emphasis on viral and host factors regulating this process.