Optic nerve head plasmacytoma as a manifestation of multiple myeloma

• Type of Material: Article
• Authors: Kaitlin Sandor, Emory University; Jonathan Micieli, University of Toronto; Jason Peragallo, Emory University
• Language: English
• Date: 2021-01-01
• Publisher: Emory University Libraries
• Publication Version: Final Published Version
• Copyright Statement: © 2021 Taiwan J Ophthalmol
• License: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.4103/tjo.tjo_81_20
• Title of Journal or Parent Work: Taiwan Journal of Ophthalmology
• Volume: 11
• Issue: 1
• Start Page: 97
• End Page: 100
• Grant/Funding Information: None.
• Keywords: Multiple myeloma; plasmacytoma; optic neuropathy; optic nerve head
• Research Categories: Health Sciences, Opthamology

Abstract

Extramedullary disease in multiple myeloma is uncommon and associated with a poorer prognosis. Extramedullary disease involving the orbit is even more unusual, with optic nerve involvement being rare. We describe an optic nerve head plasmacytoma in a 45-year-old female in the setting of systemic relapsed, refractory IgA kappa multiple myeloma. The case highlights the importance of keeping extramedullary disease spread in the differential for vision loss in a patient with a history of multiple myeloma. In addition, it describes an unusual location for presentation of extramedullary disease, the optic nerve head, which has rarely been described.