Publication

Genetic networks in mouse retinal ganglion cells

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Last modified
  • 02/25/2025
Type of Material
Authors
    Felix L. Struebing, Emory UniversityRichard K. Lee, University of MiamiRobert W. Williams, University of TennesseeEldon Geisert Jr, Emory University
Language
  • English
Date
  • 2016-09-28
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2016 Struebing, Lee, Williams and Geisert.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-8021
Volume
  • 7
Issue
  • SEP
Start Page
  • 169
End Page
  • 169
Grant/Funding Information
  • This work was supported by DoD CDMRP Grant W81XWH1210255 from the USA Army Medical Research & Materiel Command and the Telemedicine and Advanced Technology (to EG), NIH Grant R01EY017841 (to EG), Vision Core Grant P30EY006360 (to P. Michael Iuvone), and Unrestricted Funds and a Stein Innovation Award from Research to Prevent Blindness (to the Ophthalmology Department at Emory University, the University of Tennessee Health Science Center, and the Bascom Palmer Eye Institute, University of Miami Miller School of Medicine).
  • FS is supported by the institutional training grant T32EY007092-30 (to P. Michael Iuvone).
Supplemental Material (URL)
Abstract
  • Retinal ganglion cells (RGCs) are the output neuron of the eye, transmitting visual information from the retina through the optic nerve to the brain. The importance of RGCs for vision is demonstrated in blinding diseases where RGCs are lost, such as in glaucoma or after optic nerve injury. In the present study, we hypothesize that normal RGC function is transcriptionally regulated. To test our hypothesis, we examine large retinal expression microarray datasets from recombinant inbred mouse strains in GeneNetwork and define transcriptional networks of RGCs and their subtypes. Two major and functionally distinct transcriptional networks centering around Thy1 and Tubb3 (Class III beta-tubulin) were identified. Each network is independently regulated and modulated by unique genomic loci. Meta-analysis of publically available data confirms that RGC subtypes are differentially susceptible to death, with alpha-RGCs and intrinsically photosensitive RGCs (ipRGCs) being less sensitive to cell death than other RGC subtypes in a mouse model of glaucoma.
Author Notes
Keywords
Research Categories
  • Biology, Cell
  • Biology, Neuroscience
  • Biology, Genetics

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