Neuropsychiatric symptoms associated multimodal brain networks in Alzheimer's disease

• Type of Material: Article
• Authors: Kaicheng Li, Zhejiang University; Qingze Zeng, Zhejiang University; Xiao Luo, Zhejiang University; Shile Qi, Nanjing University of Aeronautics & Astronautics; Xiaopei Xu, Zhejiang University; Zening Fu, Triinst Ctr Translat Res Neuroimaging & Data Sci; Luwei Hong, Zhejiang University; Xiaocao Liu, Zhejiang University; Zheyu Li, Zhejiang University; Yanv Fu, Zhejiang University; Yanxing Chen, Zhejiang University; Zhirong Liu, Zhejiang University; Vince Calhoun, Emory University; Peiyu Huang, Zhejiang University; Minming Zhang, Zhejiang University
• Language: English
• Date: 2022-08-22
• Publisher: WILEY
• Publication Version: Final Published Version
• Copyright Statement: © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1002/hbm.26051
• Title of Journal or Parent Work: HUMAN BRAIN MAPPING
• Volume: 44
• Issue: 1
• Start Page: 119
• End Page: 130
• Grant/Funding Information: National Key Research and Development Program of China, Grant/Award Number: 2016YFC1306600; National Natural Science Foundation of China, Grant/Award Numbers: 81901707, 82001766; National Institutes of Health, Grant/Award Number: RF1AG063153
• Keywords: DEFICITS; Science & Technology; frontal-subcortical limbic circuit; DEMENTIA; Neurosciences; neuropsychiatric symptoms; FUNCTIONAL CONNECTIVITY; DEPRESSION; MILD COGNITIVE IMPAIRMENT; Life Sciences & Biomedicine; Neuroimaging; PROGRESSION; Alzheimer's disease; supervised multimodal fusion; Radiology, Nuclear Medicine & Medical Imaging; Neurosciences & Neurology; cognitive decline; COMPONENTS
• Research Categories: Health Sciences, Radiology; Computer Science; Psychology, General

Abstract

Concomitant neuropsychiatric symptoms (NPS) are associated with accelerated Alzheimer's disease (AD) progression. Identifying multimodal brain imaging patterns associated with NPS may help understand pathophysiology correlates AD. Based on the AD continuum, a supervised learning strategy was used to guide four-way multimodal neuroimaging fusion (Amyloid, Tau, gray matter volume, brain function) by using NPS total score as the reference. Loadings of the identified multimodal patterns were compared across the AD continuum. Then, regression analyses were performed to investigate its predictability of longitudinal cognition performance. Furthermore, the fusion analysis was repeated in the four NPS subsyndromes. Here, an NPS-associated pathological–structural–functional covaried pattern was observed in the frontal-subcortical limbic circuit, occipital, and sensor-motor region. Loading of this multimodal pattern showed a progressive increase with the development of AD. The pattern significantly correlates with multiple cognitive domains and could also predict longitudinal cognitive decline. Notably, repeated fusion analysis using subsyndromes as references identified similar patterns with some unique variations associated with different syndromes. Conclusively, NPS was associated with a multimodal imaging pattern involving complex neuropathologies, which could effectively predict longitudinal cognitive decline. These results highlight the possible neural substrate of NPS in AD, which may provide guidance for clinical management.