Application of an evidence-based, out-patient treatment strategy for COVID-19: Multidisciplinary medical practice principles to prevent severe disease*

• Type of Material: Article
• Authors: Elliot M. Frohman, Stanford University; Nicole R. Villemarette-Pittman, LSU Health Sciences Center; Adriana Rodriguez, Cook Childrens Medical Center; Robert Glanzman, Clene Nanomedicine Inc; Sarah Rugheimer, University of Oxford; Oleg Komogortsev, Texas State University; Scott S. Zamvil, University of California San Francisco; Roberto Alejandro Cruz, University of Texas Rio Grande Valley; Thomas C. Varkey, University of Texas Austin; Ashley N. Frohman, Frohman Foundation; Audrey R. Frohman, Frohman Foundation; Matthew Parsons, Emory University; Emily Heckmann Konkle, Frohman Foundation; Teresa C. Frohman, Stanford University
• Language: English
• Date: 2021-05-07
• Publisher: Elsevier
• Publication Version: Final Published Version
• Copyright Statement: © 2021 Published by Elsevier B.V.
• Final Published Version (URL): http://dx.doi.org/10.1016/j.jns.2021.117463
• Title of Journal or Parent Work: Journal of the Neurological Sciences
• Volume: 426
• Start Page: 117463
• End Page: 117463
• Grant/Funding Information: None declared
• Keywords: Respiratory muscle training; Mechanism; Outcomes; Add-on therapy; Postural percussion; Vitamin D; Mucus clearance; Risk; Expectorate; Leucovorin rescue; Management; Gas exchange; Life Sciences & Biomedicine; Bronchiole; Oxygen saturation; Alveoli; Neurosciences & Neurology; Clinical Neurology; Neurosciences; High dose; COVID-19; Inflammation; SARS-CoV-2; Multiple sclerosis; Acute lung injury; Pulse oximetry; Pulmonary hygiene; SARS-COV-2; Vibratory sonication; Science & Technology
• Research Categories: Biology, Neuroscience; Health Sciences, Immunology; Biology, Microbiology; Computer Science

Abstract

The COVID-19 pandemic has devastated individuals, families, and institutions throughout the world. Despite the breakneck speed of vaccine development, the human population remains at risk of further devastation. The decision to not become vaccinated, the protracted rollout of available vaccine, vaccine failure, mutational forms of the SARS virus, which may exhibit mounting resistance to our molecular strike at only one form of the viral family, and the rapid ability of the virus(es) to hitch a ride on our global transportation systems, means that we are will likely continue to confront an invisible, yet devastating foe. The enemy targets one of our human physiology's most important and vulnerable life-preserving body tissues, our broncho-alveolar gas exchange apparatus. Notwithstanding the fear and the fury of this microbe's potential to raise existential questions across the entire spectrum of human endeavor, the application of an early treatment intervention initiative may represent a crucial tool in our defensive strategy. This strategy is driven by evidence-based medical practice principles, those not likely to become antiquated, given the molecular diversity and mutational evolution of this very clever “world traveler”.