Relationship of menstrual cycle and vaginal infection in female rhesus macaques challenged with repeated, low doses of SIVmac251

• Type of Material: Article
• Authors: Monica Morris, Total Solutions; Siddappa Byrareddy, Emory University; Francois Villinger, Emory University; Tara C. Henning, Centers for Disease Control and Prevention; Katherine Butler, Centers for Disease Control and Prevention; Aftab Ansari, Emory University; Janet McNicholl, Centers for Disease Control and Prevention; Ellen Kersh, Centers for Disease Control and Prevention
• Language: English
• Date: 2015-10-01
• Publisher: Wiley: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2015 John Wiley & Sons A/S.
• Final Published Version (URL): http://dx.doi.org/10.1111/jmp.12177
• Title of Journal or Parent Work: Journal of Medical Primatology
• ISSN: 0047-2565
• Volume: 44
• Issue: 5
• Start Page: 301
• End Page: 305
• Grant/Funding Information: This work was funded by CDC and an interagency agreement (Y1-A1-0681-02) between CDC and NIH. Also supported by a grant from the NIH-NIAID AI-098628-01 (to A.A.A.), and P51 OD11132 to the Yerkes National Primate Research Center.
• Keywords: PROTECTS; Life Sciences & Biomedicine; MONKEYS; menstrual cycle; SUSCEPTIBILITY; rhesus macaque; Zoology; progesterone; SIMIAN IMMUNODEFICIENCY VIRUS; SIV; TRANSMISSION; HIV; Science & Technology; Veterinary Sciences
• Research Categories: Biology, Veterinary Science; Health Sciences, Pathology; Biology, Zoology

Abstract

Varying susceptibility during menstrual cycling could be a factor for S(H)IV infection risk in female rhesus macaques. We retrospectively determined vaginal SIV infection time points relative to the menstrual cycle in a group of rhesus macaques (n=11) enrolled in an HIV transmission trial. Eight of nine rhesus macaques became infected around menstruation time.