Family history of cancer and risk of biliary tract cancers: Results from the biliary tract cancers pooling project

• Type of Material: Article
• Authors: Alison L. Van Dyke, National Cancer Institute; Margaret S. Langhamer, National Cancer Institute; Bin Zhu, National Cancer Institute; Ruth M. Pfeiffer, National Cancer Institute; Demetrius Albanes, National Cancer Institute; Gabriella Andreotti, National Cancer Institute; Laura E. Beane Freeman, National Cancer Institute; Andrew T. Chan, Massachusetts General Hospital; Neal D. Freedman, National Cancer Institute; Susan Gapstur, Emory University; Graham G. Giles, Cancer Council Victoria; Francine Grodstein, Harvard School of Public Health; Linda M. Liao, National Cancer Institute; Juhua Luo, Indiana University; Roger L. Milne, Cancer Council Victoria; Kristine R. Monroe, Keck School of Medicine; Marian L. Neuhouser, Fred Hutchinson Cancer Research Center; Jenny N. Poynter, University of Minnesota; Mark P. Purdue, National Cancer Institute; Kim Robien, George Washington University; Catherine Schairer, National Cancer Institute; Rashmi Sinha, National Cancer Institute; Stephanie Weinstein, National Cancer Institute; Xuehong Zhang, Brigham and Women's Hospital; Jessica L. Petrick, National Cancer Institute; Katherine A. McGlynn, National Cancer Institute; Peter T. Campbell, American Cancer Society; Jill Koshiol, National Cancer Institute
• Language: English
• Date: 2018-03-01
• Publisher: American Association for Cancer Research
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2018 American Association for Cancer Research.
• Final Published Version (URL): http://dx.doi.org/10.1158/1055-9965.EPI-17-1003
• Title of Journal or Parent Work: Cancer Epidemiology, Biomarkers and Prevention
• ISSN: 1055-9965
• Volume: 27
• Issue: 3
• Start Page: 348
• End Page: 351
• Grant/Funding Information: The American Cancer Society funded the Cancer Prevention Studies (CPS), including the CPS-II Nutrition Cohort, as well as S.G. Gapstur and P.T. Campbell.; The Melbourne Collaborative Cohort Study, G. Giles, and R. Milne were funded by Vic-Health, Cancer Council Victoria, and by Australian National Health and Medical Research Council grants 209057 and 396414. Cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the National Death Index and the Australian Cancer Database.; The NIH-AARP Diet and Health Study is supported by the IRP of DCEG at NCI, part of the NIH.; Understanding Ethnic Differences in Cancer: The Multiethnic Cohort Study and K.R. Monroe received funding from the NCI (U01 CA164973).; The Iowa Women’s Health Study, K. Robien, and J. Poynter were funded through the Epidemiology and Genomics Research Program (EGRP), Division of Cancer Control and Population Sciences (DCCPS) at NCI (CA039742).; The Health Professionals Follow-up Study: Prospective Studies of Diet and Cancer in Men and Women, A.T. Chan, and X. Zhang were supported by the EGRP, DCCPS, NCI (CA055075); The Melbourne Collaborative Cohort Study was made possible by the contributions of many people, including the original investigators, the recruiting teams, and the many thousands of Melbourne residents who participated in the study.; The Breast Cancer Detection and Demonstration Project (BCDDP) is supported by the IRP of NCI, NIH and the American Cancer Society.; The Women’s Health Initiative, M.L. Neuhouser, and J. Luo are funded by the National Heart, Lung, and Blood Institute, NCI, NIH, U.S. Department of Health and Human Services through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C.; This work and the following coauthors were supported by the Intramural Research Program (IRP) of the National Institutes of Health (NIH), National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (A.L. Van Dyke, M.S. Langhamer, B. Zhu, R.M. Pfeiffer, D. Albanes, G. Andreotti, L.E. Beane Freeman, N.D. Freedman, L. Liao, M.P. Purdue, C. Schairer, R. Sinha, S. Weinstein, J.L. Petrick, K.A. McGlynn, J. Koshiol).; The Nurses’ Health Study I: Dietary and Hormonal Determinants of Cancer in Women and F. Grodstein received funding through the EGRP, DCCPS, NCI (CA087969 and CA049449).; A.T. Chan also received funding from the National Institute of Diabetes and Digestive and Kidney Diseases, NIH (K24 DK098311) and from NCI, NIH (R01 CA137178, R01 CA202704, and R01 CA176272).; The Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study is supported by the Intramural Research Program of the U.S. NCI, NIH, and by U.S. Public Health Service contract HHSN261201500005C from the NCI, Department of Health and Human Services.; NCI funded the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial through contracts.; The Agricultural Health Study is funded by the IRP of the NIH, NCI (Z01 P010119).
• Keywords: Pooling Project; Biliary Tract; Cancer; Risk; Family History
• Research Categories: Biology, Genetics; Health Sciences, Oncology; Health Sciences, Epidemiology

Abstract

Background: Although some familial cancer syndromes include biliary tract cancers (BTCs; cancers of the gallbladder, intrahepatic and extrahepatic bile ducts, and ampulla of Vater), the few studies that have examined the relationships between family history of cancer (FHC) and BTCs have reported inconclusive findings. The objective of this study was to investigate the associations of FHC with risk of BTC in the Biliary Tract Cancers Pooling Project (BiTCaPP). Methods: We used Cox proportional hazards regressions models to estimate HRs and 95% confidence intervals for associations between FHC (any, first-degree, in female relative, in male relative, relative with gastrointestinal cancer, and relative with hormonally related cancer) and BTC risk by anatomic site within the biliary tract, adjusting for sex and race/ethnicity. Sensitivity analyses were conducted that restricted to studies reporting cholecystectomy data and to people without a history of cholecystectomy. Results: Data on FHC were available from 12 prospective studies within BiTCaPP, which collectively contributed 2,246 cases (729 gallbladder, 345 intrahepatic and 615 extrahepatic bile duct, and 385 ampulla of Vater cancers) with 21,706,107 person-years of follow-up. A marginal, inverse association between FHC and gallbladder cancer was driven to the null when analysis was restricted to studies reporting cholecystectomy data and to people without a history of cholecystectomy. FHC was not associated with risk of BTC at the other anatomic sites. Conclusions: These findings do not support an association between FHC and BTCs. Impact: In a study of 1.5 million people, FHC is not a risk factor for BTCs.