The association between prenatal F2-isoprostanes and child wheeze/asthma, and modification by maternal race

• Type of Material: Article
• Authors: Robert Davis, University of Tennessee; Kaja Z. LeWinn, University of California San Francisco; Frances A. Tylavsky, University of Tennessee; Rosalind J. Wright, Icahn School of Medicine at Mount Sinai; Kecia N. Carroll, Icahn School of Medicine at Mount Sinai; Margaret A. Adgent, Vanderbilt University; Tebeb Gebretsadik, Vanderbilt University; Cordelia R. Elaiho, Icahn School of Medicine at Mount Sinai; Ginger Milne, Vanderbilt University; Paul Moore, Vanderbilt University; Terry Hartman, Emory University; Whitney Cowell, Icahn School of Medicine at Mount Sinai; Cecilia S. Alcala, Icahn School of Medicine at Mount Sinai; Nicole Bush, University of California San Francisco
• Language: English
• Date: 2022-08-20
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2022 Elsevier Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): https://doi.org/10.1016/j.freeradbiomed.2022.07.008
• Title of Journal or Parent Work: Free Radical Biology and Medicine
• Volume: 189
• Start Page: 85
• End Page: 90
• Grant/Funding Information: This work was supported by the Urban Child Institute, NIH R01 HL109977, NIH R01 HL132338, NIH R01 K24 HL150312, P30 ES023515, and the Vanderbilt Institute for Clinical and Translational Research Grant Number: UL1RR024975.
• Keywords: asthma; wheezing; isoprostane; pediatric; oxidative stress; allergic rhinitis; prenatal
• Research Categories: Health Sciences, Epidemiology; Health Sciences, Obstetrics and Gynecology

Abstract

Background: Childhood wheeze, asthma, and allergic rhinitis are common and likely have prenatal origins. Oxidative stress is associated with respiratory disease, but the association of oxidative stress during the prenatal period with development of respiratory and atopic disease in childhood, particularly beyond the infancy period, is unknown. This study aims to investigate associations between prenatal oxidative stress, measured by maternal urinary F2-isoprostanes, and child respiratory outcomes, including effect modification by maternal race. Methods: We prospectively studied Black (n=717) and White (n=363) mother-child dyads. We measured F2-isoprostanes in 2nd-trimester urine (ng/mg-creatinine). At approximately age 4, we obtained parent report of provider-diagnosed asthma (ever), current wheeze, current asthma (diagnosis, symptoms and/or medication), and current allergic rhinitis (current defined as previous 12 months). We used multivariable logistic regression to estimate adjusted odds ratios (aOR) and 95% confidence intervals (95%CI) per interquartile range (IQR) increase in F2-isoprostane concentration, controlling for confounders. We examined modification by maternal race using interaction terms. Results: The prevalence of provider-diagnosed asthma and current wheeze, asthma and allergic rhinitis was 14%, 19%, 15%, and 24%, respectively. Median (IQR) F2-isoprostane levels were 2.1 (1.6, 2.9) ng/mg-creatinine. Associations between prenatal F2-isoprostanes and provider-diagnosed asthma, current wheeze, and current asthma were modified by maternal race. Results were strongest for current wheeze (aOR [95%CI]: 1.55 [1.16, 2.06] for White; 0.98 [0.78, 1.22] for Black; p-interaction=0.01). We observed no association between F2-isoprostanes and allergic rhinitis. Conclusion: Prenatal urinary F2-isoprostanes may be a marker associated with childhood wheeze/asthma in certain populations. Research is needed to understand underlying mechanisms and racial differences.