Initial Assessment of Lactate as Mediator of Exercise-Induced Retinal Protection

• Type of Material: Article
• Authors: Jana T. Sellers, Emory University; Micah A. Chrenek, Emory University; Preston E. Girardot, Emory University; John Nickerson, Emory University; Machelle Pardue, Emory University; Jeffrey Boatright, Emory University
• Language: English
• Date: 2019-01-01
• Publisher: Springer International Publishing A.G.
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © Springer Nature Switzerland AG 2019, Corrected Publication 2020.
• Final Published Version (URL): http://dx.doi.org/10.1007/978-3-030-27378-1_74
• Title of Journal or Parent Work: Retinal Degenerative Diseases: Mechanisms and Experimental Therapy
• Volume: 1185
• Start Page: 451
• End Page: 455
• Grant/Funding Information: NIH R01EY028859, R01EY028450, R01EY021592, T32EY07092, and P30EY006360; and an unrestricted grant from Research to Prevent Blindness, Inc.; The Abraham J. & Phyllis Katz Foundation; VA RR&D Center Grant C9246C,; Research Career Scientist Award C9257, Merit Award I01RX002806, and SPiRE Award Number I21RX001924
• Keywords: Science & Technology; Mouse; Exercise; Transport; Retinal degeneration; Lactate; Medicine, Research & Experimental; Brain-derived neurotrophic factor; Roles; Neuroprotection; Degeneration; Ophthalmology; Research & Experimental Medicine; BDNF; Life Sciences & Biomedicine

Abstract

Physical exercise is protective in rodent models of retinal injury and disease. Data suggest that this is in part mediated by brain-derived neurotrophic factor (BDNF) signal transduction. It has been hypothesized that exercised-induced neuroprotection may be mediated by increases in circulating lactate that in turn alter BDNF secretion. We therefore tested whether mice undergoing a treadmill running regimen previously shown to be protective in a mouse model of retinal degeneration (RD) have increased serum levels of lactate. Lactate levels in exercised and non-exercised mice were statistically indistinguishable. A role for circulating lactate in exercise-induced retinal protection is unsupported.