Sociodemographic disparities in the occurrence of medical conditions among adolescent and young adult Hodgkin lymphoma survivors

• Type of Material: Article
• Authors: Theresa H.M. Keegan, University of California, Davis; Qian Li, University of California, Davis; Amy Steele, University of California, Davis; Elysia Alvarez, University of California, Davis; Ann Brunson, University of California, Davis; Christopher R Flowers, Emory University; Sally L. Glaser, Cancer Prevention Institute of California; Ted Wun, University of California, Davis
• Language: English
• Date: 2018-06-01
• Publisher: Springer (part of Springer Nature): Springer Open Choice Hybrid Journals
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2018, Springer International Publishing AG, part of Springer Nature.
• Final Published Version (URL): http://dx.doi.org/10.1007/s10552-018-1025-0
• Title of Journal or Parent Work: Cancer Causes and Control
• ISSN: 0957-5243
• Volume: 29
• Issue: 6
• Start Page: 551
• End Page: 561
• Grant/Funding Information: This work was supported by the Rich and Weissman Family Lymphoma and Survivorship Fund St. Baldrick’s Research Grant.; The collection of cancer incidence data used in this study was supported by the California Department of Public Health as part of the statewide cancer reporting program mandated by California Health and Safety Code Section 103885; the National Cancer Institute’s Surveillance, Epidemiology and End Results Program under contract HHSN261201000140C awarded to the Cancer Prevention Institute of California; contract HHSN261201000035C awarded to the University of Southern California; and contract HHSN261201000034C awarded to the Public Health Institute; and the Centers for Disease Control and Prevention’s National Program of Cancer Registries, under agreement U58DP003862-01 awarded to the California Department of Public Health.; In addition, Dr. Flowers’ effort was supported by National Cancer Institute U01CA195568 and K24CA208132, and Dr. Wun’s effort also supported by National Center for Advancing Translational Sciences TR000002.
• Keywords: Hodgkin lymphoma; THERAPY; Young adult; HOSPITALIZATION; MORTALITY; CANCER SURVIVORS; Circulatory system; HEALTH-INSURANCE; Race/ethnicity; CARE; Second cancer; Endocrine system; LONG-TERM SURVIVORS; Oncology; RISK; Insurance; Adolescent; REGISTRY DATA; Science & Technology; Public, Environmental & Occupational Health; Respiratory system; SOCIOECONOMIC-STATUS; Life Sciences & Biomedicine
• Research Categories: Health Sciences, Public Health; Health Sciences, Oncology

Abstract

Purpose: Hodgkin lymphoma (HL) survivors experience high risks of second cancers and cardiovascular disease, but no studies have considered whether the occurrence of these and other medical conditions differ by sociodemographic factors in adolescent and young adult (AYA) survivors. Methods: Data for 5,085 patients aged 15–39 when diagnosed with HL during 1996–2012 and surviving ≥ 2 years were obtained from the California Cancer Registry and linked to hospitalization data. We examined the impact of race/ethnicity, neighborhood socioeconomic status (SES), and health insurance on the occurrence of medical conditions (≥ 2 years after diagnosis) and the impact of medical conditions on survival using multivariable Cox proportional hazards regression. Results: Twenty-six percent of AYAs experienced at least one medical condition and 15% had ≥ 2 medical conditions after treatment for HL. In multivariable analyses, Black HL survivors had a higher likelihood (vs. non-Hispanic Whites) of endocrine [hazard ratio (HR) = 1.37, 95% confidence interval (CI) 1.05–1.78] and circulatory system diseases (HR = 1.58, CI 1.17–2.14); Hispanics had a higher likelihood of endocrine diseases [HR = 1.24 (1.04–1.48)]. AYAs with public or no insurance (vs. private/military) had higher likelihood of circulatory system diseases, respiratory system diseases, chronic kidney disease/renal failure, liver disease, and endocrine diseases. AYAs residing in low SES neighborhoods (vs. high) had higher likelihood of respiratory system and endocrine diseases. AYAs with these medical conditions or second cancers had an over twofold increased risk of death. Conclusion: Strategies to improve health care utilization for surveillance and secondary prevention among AYA HL survivors at increased risk of medical conditions may improve outcomes.