Publication

Significance of Microbiota in Obesity and Metabolic Diseases and the Modulatory Potential by Medicinal Plant and Food Ingredients.

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Last modified
  • 03/03/2025
Type of Material
Authors
    Hoda M. Eid, Natural Health Products and Metabolic Diseases LaboratoryMichelle L. Wright, Emory UniversityN.V Anil Kumar, Manipal UniversityAbdel Qawasmeh, Hebron UniversitySherif T. S. Hassan, University of Veterinary and Pharmaceutical Sciences BrnoAndrei Mocan, Iuliu Hatieganu University of Medicine and PharmacySeyed M. Nabavi, Baqiyatallah University of Medical SciencesLuca Rastrelli, University of SalernoAtanas G. Atanasov, Institute of Genetics and Animal BreedingPierre S. Haddad, Natural Health Products and Metabolic Diseases Laboratory
Language
  • English
Date
  • 2017
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2017 Eid, Wright, Anil Kumar, Qawasmeh, Hassan, Mocan, Nabavi, Rastrelli, Atanasov and Haddad.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1663-9812
Volume
  • 8
Start Page
  • 387
End Page
  • 387
Grant/Funding Information
  • AA acknowledges the support by the Polish KNOW (Leading National Research Centre) Scientific Consortium “Healthy Animal—Safe Food,” decision of Ministry of Science and Higher Education No. 05-1/KNOW2/2015, and by the Austrian Science Fund (FWF): P25971–B23.
Abstract
  • Metabolic syndrome is a cluster of three or more metabolic disorders including insulin resistance, obesity, and hyperlipidemia. Obesity has become the epidemic of the twenty-first century with more than 1.6 billion overweight adults. Due to the strong connection between obesity and type 2 diabetes, obesity has received wide attention with subsequent coining of the term "diabesity." Recent studies have identified unique contributions of the immensely diverse gut microbiota in the pathogenesis of obesity and diabetes. Several mechanisms have been proposed including altered glucose and fatty acid metabolism, hepatic fatty acid storage, and modulation of glucagon-like peptide (GLP)-1. Importantly, the relationship between unhealthy diet and a modified gut microbiota composition observed in diabetic or obese subjects has been recognized. Similarly, the role of diet rich in polyphenols and plant polysaccharides in modulating gut bacteria and its impact on diabetes and obesity have been the subject of investigation by several research groups. Gut microbiota are also responsible for the extensive metabolism of polyphenols thus modulating their biological activities. The aim of this review is to shed light on the composition of gut microbes, their health importance and how they can contribute to diseases as well as their modulation by polyphenols and polysaccharides to control obesity and diabetes. In addition, the role of microbiota in improving the oral bioavailability of polyphenols and hence in shaping their antidiabetic and antiobesity activities will be discussed.
Author Notes
Keywords
Research Categories
  • Health Sciences, Public Health
  • Health Sciences, Medicine and Surgery

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