Performance of the Universal Vital Assessment (UVA) mortality risk score in hospitalized adults with infection in Rwanda: A retrospective external validation study

• Type of Material: Article
• Authors: Riley Hazard, University of Melbourne; Danstan Bagenda, University of Nebraska Medical Center; Andrew Patterson, Emory University; Julia T Hoffman, University of Nebraska Medical Center; Steven J Lisco, University of Nebraska Medical Center; Olivier Urayeneza, University of Gitwe; Polyphile Ntihinyurwa, University of Rwanda; Christopher C Moore, University of Virginia
• Language: English
• Date: 2022-01-01
• Publisher: PUBLIC LIBRARY SCIENCE
• Publication Version: Final Published Version
• Copyright Statement: © 2022 Hazard et al
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1371/journal.pone.0265713
• Title of Journal or Parent Work: PLOS ONE
• Volume: 17
• Issue: 3
• Start Page: e0265713
• End Page: e0265713
• Grant/Funding Information: The original study enrollment, the data from which the authors performed retrospective analyses, was funded by the Life Priority Fund, the Hellman Foundation, and the King Baudouin Foundation. The original research project was also supported by the European Society of Intensive Care Medicine and the Society of Critical Care Medicine through the Surviving Sepsis Campaign. The secondary analysis described in this paper was supported by the University of Virginia Global Infectious Diseases Institute. The funders had no additional role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.
• Keywords: Multidisciplinary Sciences; Science & Technology - Other Topics; Science & Technology; QSOFA SCORE; SEPSIS; TUBERCULOSIS
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Background We previously derived a Universal Vital Assessment (UVA) score to better risk-stratify hospitalized patients in sub-Saharan Africa, including those with infection. Here, we aimed to externally validate the performance of the UVA score using previously collected data from patients hospitalized with acute infection in Rwanda. Methods We performed a secondary analysis of data collected from adults ≥18 years with acute infection admitted to Gitwe District Hospital in Rwanda from 2016 until 2017. We calculated the UVA score from the time of admission and at 72 hours after admission. We also calculated quick sepsis-related organ failure assessment (qSOFA) and modified early warning scores (MEWS). We calculated amalgamated qSOFA scores by inserting UVA cut-offs into the qSOFA score, and modified UVA scores by removing the HIV criterion. The performance of each score determined by the area under the receiver operator characteristic curve (AUC) was the primary outcome measure. Results We included 573 hospitalized adult patients with acute infection of whom 40 (7%) died in-hospital. The admission AUCs (95% confidence interval [CI]) for the prediction of mortality by the scores were: UVA, 0.77 (0.68–0.85); modified UVA, 0.77 (0.68–0.85); qSOFA, 0.66 (0.56–0.75), amalgamated qSOFA, 0.71 (0.61–0.80); and MEWS, 0.74 (0.64, 0.83). The positive predictive values (95% CI) of the scores at commonly used cut-offs were: UVA >4, 0.35 (0.15–0.59); modified UVA >4, 0.35 (0.15–0.59); qSOFA >1, 0.14 (0.07–0.24); amalgamated qSOFA >1, 0.44 (0.20–0.70); and MEWS >5, 0.14 (0.08–0.22). The 72 hour (N = 236) AUC (95% CI) for the prediction of mortality by UVA was 0.59 (0.43–0.74). The Chi-Square test for linear trend did not identify an association between mortality and delta UVA score at 72 hours (p = 0.82). Conclusions The admission UVA score and amalgamated qSOFA score had good predictive ability for mortality in adult patients admitted to hospital with acute infection in Rwanda. The UVA score could be used to assist with triage decisions and clinical interventions, for baseline risk stratification in clinical studies, and in a clinical definition of sepsis in Africa.