Differing associations of PM2.5 exposure with systolic and diastolic blood pressures across exposure durations in a predominantly non-Hispanic Black cohort

• Type of Material: Article
• Authors: Jiajun Luo, University of Chicago; Rena R. Jones, National Cancer Institute; Zhihao Jin, Emory University; Tamar Polonsky, University of Chicago; Karen Kim, University of Chicago; Christopher O. Olopade, University of Chicago; Jayant Pinto, University of Chicago; Habibul Ahsan, University of Chicago; Briseis Aschebrook-Kilfoy, University of Chicago
• Language: English
• Date: 2024-08-31
• Publisher: Springer Nature
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s) 2024
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): https://doi.org/10.1038/s41598-024-64851-6
• Title of Journal or Parent Work: Scientific Reports
• Volume: 14
• Start Page: 20256
• Grant/Funding Agency: NIH; University of Chicago
• Grant/Funding Information: This research was supported by funding from NIH grants P30ES027792 and U2RTW010122, and the University of Chicago Medicine Comprehensive Cancer Center.
• Keywords: blood pressures; Preclinical research; fine particulate matter
• Subject - Topics: Epidemiology; Environmental health

Abstract

Environmental health research has suggested that fine particulate matter (PM2.5) exposure can lead to high blood pressures, but it is unclear whether the impacts remain the same for systolic and diastolic blood pressures (SBP and DBP). This study aimed to examine whether the effects of PM2.5 exposure on SBP and DBP differ using data from a predominantly non-Hispanic Black cohort collected between 2013 and 2019 in the US. PM2.5 exposure was assessed based on a satellite-derived model across exposure durations from 1 to 36 months. The average PM2.5 exposure level was between 9.5 and 9.8 μg/m3 from 1 through 36 months. Mixed effects models were used to estimate the association of PM2.5 with SBP, DBP, and related hypertension types, adjusted for potential confounders. A total of 6381 participants were included. PM2.5 exposure was positively associated with both SBP and DBP. The association magnitudes depended on exposure durations. The association with SBP was null at the 1-month duration (β = 0.05, 95% CI: − 0.23, 0.33), strengthened as duration increased, and plateaued at the 24-month duration (β = 1.14, 95% CI: 0.54, 1.73). The association with DBP started with β = 0.29 (95% CI: 0.11, 0.47) at the 1-month duration, and plateaued at the 12-month duration (β = 1.61, 95% CI: 1.23, 1.99). PM2.5 was associated with isolated diastolic hypertension (12-month duration: odds ratio = 1.20, 95% CI: 1.07, 1.34) and systolic–diastolic hypertension (12-month duration: odds ratio = 1.18, 95% CI: 1.10, 1.26), but not with isolated systolic hypertension. The findings suggest DBP is more sensitive to PM2.5 exposure and support differing effects of PM2.5 exposure on SBP and DBP. As elevation of SBP and DBP differentially predict CVD outcomes, this finding is relevant for prevention and treatment.