Rationale and design of the Randomized Evaluation of patients with Stable angina Comparing Utilization of noninvasive Examinations (RESCUE) trial

• Type of Material: Article
• Authors: Arthur Stillman, Emory University; Constantine Gatsonis, Brown University; João A. C Lima, Johns Hopkins University; William C. Black, Dartmouth-Hitchcock Medical Center; Jean Cormack, Brown University; Ilana Gareen, Brown University; Udo Hoffmann, Massachusetts General Hospital; Tao Liu, Brown University; Kreton Mavromatis, Emory University; Mitchell D. Schnall, University of Pennsylvania; James E. Udelson, Tufts-New England Medical Center; Pamela K. Woodard, Washington University
• Language: English
• Date: 2016-09-01
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2015 Elsevier, Inc.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.ahj.2016.06.003
• Title of Journal or Parent Work: American Heart Journal
• ISSN: 0002-8703
• Volume: 179
• Start Page: 19
• End Page: 28
• Keywords: PCI; COMPUTED-TOMOGRAPHY; Cardiovascular System & Cardiology; QUESTIONNAIRE; Cardiac & Cardiovascular Systems; CORONARY-ARTERY-DISEASE; RECLASSIFICATION; DIAGNOSTIC-ACCURACY; QUALITY-OF-LIFE; Science & Technology; MYOCARDIAL-PERFUSION; ANGIOGRAPHY; PECTORIS; Life Sciences & Biomedicine
• Research Categories: Health Sciences, Radiology; Health Sciences, Public Health

Abstract

RESCUE is a phase III, randomized, controlled, multicenter, comparative efficacy study, designed to compare two diagnostic imaging/treatment paradigms that use coronary computed tomography angiography (CCTA) or single photon emission computed tomography myocardial perfusion imaging (SPECT MPI) for assisting in the diagnosis of ischemic heart disease in patients with stable angina symptoms, and guiding subsequent treatment. The study is based on the hypothesis that CCTA as a diagnostic tool is associated with no increase in cardiac risk, decreased cost, and reduced radiation exposure compared with SPECT MPI. The RESCUE trial was funded by the Agency for Healthcare Research and Quality (AHRQ) and the American College of Radiology Imaging Network (ACRIN) Fund for Imaging Innovation, began in 2011, and completed in 2014.