A mouse model of HIV-associated neurocognitive disorders: a brain-behavior approach to discover disease mechanisms and novel treatments

• Type of Material: Article
• Authors: William Tyor, Emory University; Heather Bimonte-Nelson, Arizona State University
• Language: English
• Date: 2018-04-01
• Publisher: Taylor & Francis: STM, Behavioural Science and Public Health Titles
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © Journal of NeuroVirology, Inc. (outside the USA) 2017.
• Final Published Version (URL): http://dx.doi.org/10.1007/s13365-017-0572-6
• Title of Journal or Parent Work: Journal of NeuroVirology
• ISSN: 1355-0284
• Volume: 24
• Issue: 2
• Start Page: 180
• End Page: 184
• Keywords: Science & Technology; Virology; INTERFERON-ALPHA; ENCEPHALITIS; HUMAN-IMMUNODEFICIENCY-VIRUS; COGNITIVE DYSFUNCTION; MEMORY; ACTIVE ANTIRETROVIRAL THERAPY; ABNORMALITIES; Life Sciences & Biomedicine; ERA; Neurocognitive disorders; HIV; Neurosciences & Neurology; Neurosciences; Animal model; SCID MICE
• Research Categories: Health Sciences, Medicine and Surgery; Biology, Virology; Health Sciences, Immunology

Abstract

HIV-associated neurocognitive disorders (HAND) remain highly prevalent despite combined antiretroviral therapy (cART). Although the most common forms of HAND are mild and identified through neuropsychological testing, there is evidence that with aging these mild forms become more prevalent and may advance to the most severe form of HAND, HIV-associated dementia. Therefore, novel therapies must be developed that can be used adjunctively with cART to prevent deterioration or restore normal cognitive function. In order to develop innovative treatments, animal models are used for preclinical testing. Ideally, a HAND animal model should portray similar mild cognitive deficits that are found in humans. A mouse model of HAND is discussed, which demonstrates mild behavioral deficits and has been used to investigate cART and novel treatments for HAND. This model also shows correlations between abnormal mouse behavior due to HIV in the brain and pathological parameters such as gliosis and neuronal abnormalities. A recent advancement utilizes the object recognition test to monitor mouse behavior before and after treatment. It is postulated that this model is well suited for preclinical testing of novel therapies and provides correlations of mild cognitive impairment with pathological markers that can give further insight into the pathophysiology of HAND.